Results 11 to 20 of about 217,248 (344)

G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions [PDF]

Purinergic Signalling, 2012
The medicinal chemistry and pharmacology of the four subtypes of adenosine receptors (ARs) and the eight subtypes of P2Y receptors (P2YRs, activated by a range of purine and pyrimidine mono- and dinucleotides) has recently advanced significantly leading to selective ligands.
Kenneth A. Jacobson, Рамачандран Баласубраманиан, Francesca Deflorian, Zhan‐Guo Gao   +3 more
openalex   +4 more sources

Vimentin Is an Attachment Receptor for Mycoplasma pneumoniae P1 Protein

Microbiology Spectrum, 2023
Mycoplasma pneumoniae is the most common pathogen causing respiratory tract infection, and the P1 protein on its adhesion organelle plays a crucial role during the pathogenic process. A variety of experiments, including enzyme-linked immunosorbent assay (ELISA), coimmunoprecipitation, adhesion, and adhesion inhibition assay ...
Kailan Peng, Yating Liao, Xia Li, Dongdong Zeng, Youyuan Ye, Li Chen, Zhuo Zeng, Yanhua Zeng   +7 more
openalex   +3 more sources

Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse

Nature Communications, 2022
NKR-P1 is an inhibitory receptor on the surface of natural killer cells, and its engagement with the ligand LLT1 on activated monocytes and B cells triggers NK cell self-tolerance and other immunological processes.
Jan Bláha, Tereza Skálová, Barbora Kalousková, Ondřej Skořepa, Denis Cmunt, Valéria Grobárová, Samuel Pazicky, Edita Poláchová, Celeste Abreu, Jan Stránský, Tomáš Kovaľ, Jarmila Dušková, Yuguang Zhao, Karl Harlos, Jindřich Hašek, Jan Dohnálek, Ondřej Vaněk   +16 more
doaj   +1 more source

P1 receptors and cytokine secretion [PDF]

Purinergic Signalling, 2007
Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms.
M.P. Abbracchio, S. Ceruti
openaire   +2 more sources

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +9 more sources

P1 and P2 Purine and Pyrimidine Receptor Ligands

, 2001
Research focused on P1 and P2 purinergic receptor function is currently at a critical stage where considerable efforts in the disciplines of medicinal chemistry, molecular biology, and pharmacology have resulted in the identification of a number of novel ligands that have been used to enhance understanding of the roles of both P1 (adenosine) and P2 ...
Kenneth A. Jacobson, Lars J. S. Knutsen
openalex   +3 more sources

The Protective HIV-1 Envelope gp41 Antigen P1 Acts as a Mucosal Adjuvant Stimulating the Innate Immunity

Frontiers in Immunology, 2021
Mucosal nasal vaccine development, although ideal to protect from pathogens invading mucosally, is limited by the lack of specific adjuvant. We recently used P1, a conserved region of HIV-1 gp41-envelope glycoprotein, as efficient antigen in a ...
Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +8 more
doaj   +1 more source

In silico identification and experimental validation of cellular uptake by a new cell penetrating peptide P1 derived from MARCKS

Drug Delivery, 2021
Viral vectors for vaccine delivery are challenged by recently reported safety issues like immunogenicity and risk for cancer development, and thus there is a growing need for the development of non-viral vectors.
Linlin Chen, Xiangli Guo, Lidan Wang, Jingping Geng, Jiao Wu, Bin Hu, Tao Wang, Jason Li, Changbai Liu, Hu Wang   +9 more
doaj   +1 more source

Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection. [PDF]

J Innate Immun, 2015
Aguilar OA, Mesci A, Ma J, Chen P, Kirkham CL, Hundrieser J, Voigt S, Allan DS, Carlyle JR.   +8 more
europepmc   +3 more sources

KLF2 Inhibits Chicken Preadipocyte Differentiation at Least in Part via Directly Repressing PPARγ Transcript Variant 1 Expression

Frontiers in Cell and Developmental Biology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two ...
Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Jiaxin Huang, Jiaxin Huang, Jiaxin Huang, Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Bolin Ning, Bolin Ning, Bolin Ning, Fang Mu, Fang Mu, Fang Mu, Xin You, Xin You, Xin You, Yaqi Guo, Yaqi Guo, Yaqi Guo, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +28 more
doaj   +1 more source