Results 21 to 30 of about 217,248 (344)
A dual regulation mechanism of histidine kinase CheA identified by combining network-dynamics modeling and system-level input-output data. [PDF]
PLoS Computational Biology, 2018 It is challenging to decipher molecular mechanisms in biological systems from system-level input-output data, especially for complex processes that involve interactions among multiple components.
Bernardo A Mello +3 more
doaj +1 more source
Journal of Pharmacological Sciences, 2004 Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj +1 more source
Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?
Cells, 2021 Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi +5 more
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Modelling and analysis of biochemical signalling pathway cross-talk [PDF]
, 2010 Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing ...
Emanuela Merelli +3 more
core +5 more sources
Variation in the Thyrotropic Activity of Human Chorionic Gonadotropin in Chinese Hamster Ovary Cells Arises from Differential Expression of the Human Thyrotropin Receptor and Microheterogeneity of the Hormone. [PDF]
, 1995 The role of hCG as a stimulator of the human thyroid has been a subject of controversy, because discrepant results have been obtained in different in vitro assays.
Amir, S.M. +4 more
core +1 more source
Communications Biology, 2023 Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin
John V. Dzimianski +12 more
doaj +1 more source
Biomedicines, 2021 The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild ...
Micaela Morettini +6 more
doaj +1 more source
RAGs and Regulation of Autoantibodies [PDF]
, 2004 Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael +4 more
core +1 more source
Axon regeneration after optic nerve injury in rats can be improved via PirB knockdown in the retina
Cell & Bioscience, 2021 Background In the central nervous system (CNS), three types of myelin-associated inhibitors (MAIs) exert major inhibitory effects on nerve regeneration: Nogo-A, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp).
Mei Yang +8 more
doaj +1 more source
Scientific Reports, 2023 Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions.
Jahg Wong +8 more
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