Results 141 to 150 of about 736,547 (297)
Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]
, 2010 Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Giant Magnetic Purcell Effect Induced by High‐Order Mie Resonances
Advanced Science, EarlyView.High‐order Mie resonances in dielectric spheres selectively amplify magnetic dipole emission from Eu3+ emitters, producing a giant magnetic Purcell effect. Localized emitters can efficiently access high‐order resonant modes, and the low‐loss TiO2 platform enables direct far‐field observation of the enhanced emission.
Haonan Shi +6 more
wiley +1 more source
Advanced Science, EarlyView.TAB–2TFSI enables efficient ion‐pair doping across a wide range of conjugated polymers, where the strongly oxidizing TAB core drives charge transfer, and the TFSI counterions promote favorable ionic compensation. This dicationic dopant promotes uniform dopant distribution, improves structural order, and increases carrier delocalization, establishing a ...
Juhyung Park +14 more
wiley +1 more source
Advanced Science, EarlyView.LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao +13 more
wiley +1 more source
Advanced Science, EarlyView.Precise characterization of n‐type organic semiconductors necessitates decoupling interfacial constraints from intrinsic charge transport. This work reveals that disordered polymers are particularly vulnerable to contact‐limited bottlenecks compared to their crystalline counterparts.
Walid Boukhili +15 more
wiley +1 more source
P1-237 Post-separation parenting arrangements: patterns and developmental outcomes
, 2011 P1-237 Post-separation parenting arrangements: patterns and developmental ...
J Mcintosh (15819725) +2 more
core
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source
Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery
Advanced Science, EarlyView.A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li +9 more
wiley +1 more source