Results 201 to 210 of about 736,547 (297)

OBSERVATIONS ON THE BLOOD GROUP RECEPTOR P1 AND ITS DEVELOPMENT IN CHILDREN [PDF]

Hereditas, 2009
openaire   +1 more source

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

From Berzelius to Hyperspace: Previously Unrecognized Network of Reactivity in Textbook Brominations

Angewandte Chemie, EarlyView.
Robotic scans across multidimensional condition spaces of classic bromination reactions uncover regions of previously unrecognized reactivity, yielding new major products and novel substitution patterns. Correlation and anticorrelation analyses of product distributions across these hyperspaces enable reconstruction of the underlying mechanistic ...
Yankai Jia, Wai‐Shing Wong, Yasemin Bilgi‐Gadina, Louis P. J.‐L. Gadina, King‐Lam Kwong, Yanqiu Jiang, Nikolaos Vagkidis, Benito Marazzi, Peter R. Schreiner, Bartosz A. Grzybowski   +9 more
wiley   +2 more sources

Lattice Ultrasensitivity Amplifies Signals in <i>E. coli</i> without Finely-Tuned Allosteric Interactions. [PDF]

PRX Life
Sherry DM, Graf IR, Bryant SJ, Emonet T, Machta BB.   +4 more
europepmc   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Pinostrobin pentanoate as a selective estrogen receptor-<i>α</i> antagonist in breast cancer: integrated <i>in silico</i> and <i>in vitro</i> evaluation. [PDF]

Res Pharm Sci
Widiandani T, Susilawati D, Rahman A, Rahmah S, Sulistyowaty MI, Suryadi AMA, Purwanto BT, Siswodihardjo S.   +7 more
europepmc   +1 more source

A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results. [PDF]

Age Ageing
Bianchi F, Broers B, Desmeules JA, Langlois A, Wampfler J, Curtin F, Pautex S.   +6 more
europepmc   +1 more source

Investigating the fruitless-directed molecular and circuit architecture of courtship behavior in Drosophila melanogaster, Drosophila simulans, and their hybrids. [PDF]

Genetics
Palmateer CM, Morris KC, Nolting S, Mast J, Arbeitman MN.   +4 more
europepmc   +1 more source

Single-Cell Transcriptomic Analysis of Macaque LGN Neurons Reveals Novel Subpopulations. [PDF]

Mol Neurobiol
Sun SH, Renshaw KT, Pezaris JS.
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source