Results 131 to 140 of about 481,863 (320)

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Journal of Cell Biology, 2016
Lambrus et al. show that centrosome loss or a prolonged mitosis activates a USP28–53BP1–p53–p21 signaling axis that prevents the growth of cells with an increased propensity for mitotic errors.
Bramwell G. Lambrus, V. Daggubati, Yumi Uetake, Phillip Scott, Kevin M. Clutario, G. Sluder, A. Holland   +6 more
semanticscholar   +1 more source

Structural Exploration of Zirconium Metal–Organic Frameworks Through Linker Desymmetrization and Modulator Compensation

Advanced Materials, EarlyView.
A linker‐desymmetrization‐modulator‐compensation (LDMC) strategy for constructing structurally diverse Zr‐MOFs is reported. This approach reduces linker symmetry to create defects in Zr‐clusters, which can be compensated for by modulator coordination. Using this approach, we synthesized PCN‐1005 and PCN‐1006, featuring unprecedented Zr‐clusters. In PCN‐
Rong‐Ran Liang, Kun‐Yu Wang, Zongsu Han, Kui Tan, Yihao Yang, Zhaoyi Liu, Joshua Rushlow, Jiatong Huo, Hong‐Cai Zhou   +8 more
wiley   +1 more source

Functional Characterization of LTR12C as Regulators of Germ-Cell-Associated TA-p63 in U87-MG and T98-G In Vitro Models

Cells
Glioblastoma multiforme (GBM) is a deadly disease known for its genetic heterogeneity. LTR12C is an endogenous retrovirus-derived regulator of pro-apoptotic genes and is normally silenced by epigenetic regulation.
Lucia Meola, Sohum Rajesh Shetty, Angelo Peschiaroli, Claudio Sette, Camilla Bernardini   +4 more
doaj   +1 more source

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Nature Aging, 2021
Binsheng Wang, Lichao Wang, Nathan S. Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R. Jellison, L. Haynes, S. Yadav, T. Tchkonia, G. Kuchel, J. Kirkland, Ming Xu   +12 more
semanticscholar   +1 more source

LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson's Disease through Activating α-Synuclein Expression

BioMed Research International, 2018
Long intergenic noncoding RNA-p21 (lincRNA-p21) has been reported to be increased in Parkinson's disease (PD). However, the function and underlying mechanisms of lincRNA-p21 remain not clear.
Xiaonan Xu, C. Zhuang, Zimu Wu, Hongyan Qiu, Haixia Feng, Jun Wu   +5 more
semanticscholar   +1 more source

Bicomplex Hamiltonian systems in Quantum Mechanics

, 2015
We investigate bicomplex Hamiltonian systems in the framework of an analogous version of the Schrodinger equation. Since in such a setting three different types of conjugates of bicomplex numbers appear, each is found to define in a natural way, a ...
Bagchi, Bijan, Banerjee, Abhijit
core   +1 more source

Bay‐functionalized [7]Helicene Bilayer Nanographenes

Advanced Optical Materials, EarlyView.
Bay‐functionalized [7]helical bilayer nanographenes are synthesized via a scalable, modular strategy enabling late‐stage diversification. Tailored methoxy, diketone, and phenazine substitutions precisely tune redox, photophysical, and chiroptical properties, delivering strong electronic circular dichroism and bright circularly polarized luminescence ...
Anmol Thanai, Vikas Sharma, Louis Minion, Hassan Khan, Hadeel Abbas, George F. S. Whitehead, Avantika Hasija, Jessica Wade, Matthew John Fuchter, Ashok Keerthi   +9 more
wiley   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage

Advanced Science, EarlyView.
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su, Sisheng Zhang, Lidi Liang, Haiyi Bai, Mei Bai, Hanjun He, Yayu Wang, Huan Liu, Xiangxiu Liang, Yu Sun, Hong Wu   +10 more
wiley   +1 more source

LincRNA-p21 Inhibits the Wnt/β-Catenin Pathway in Activated Hepatic Stellate Cells via Sponging MicroRNA-17-5p

Cellular Physiology and Biochemistry, 2017
Background/Aims: It is known that the activation of hepatic stellate cells (HSCs) is a pivotal step in the initiation and progression of liver fibrosis.
F. Yu, Yong Guo, Bicheng Chen, Liang Shi, Peihong Dong, Mengtao Zhou, Jianjian Zheng   +6 more
semanticscholar   +1 more source