Results 11 to 20 of about 481,863 (320)
CPEB4 Inhibit Cell Proliferation via Upregulating p21 mRNA Stability in Renal Cell Carcinoma
Frontiers in Cell and Developmental Biology, 2021 Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) has been reported to be dysregulated in a variety of cancers and seems to play paradoxical roles in different cancers.
Jiehui Di +16 more
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Nature Communications, 2022 A major obstacle in diabetes is the metabolic or hyperglycemic memory, which lacks specific therapies. Here we show that glucose-mediated changes in gene expression largely persist in diabetic kidney disease (DKD) despite reversing hyperglycemia.
M. M. Al-Dabet +24 more
semanticscholar +1 more source
Nature Communications, 2021 Since their discovery as drivers of proliferation, cyclin-dependent kinases (CDKs) have been considered therapeutic targets. Small molecule inhibitors of CDK4/6 are used and tested in clinical trials to treat multiple cancer types. Despite their clinical
semanticscholar +1 more source
Nucleic Acids Research, 2021 Mammalian circRNAs can influence different cellular processes by interacting with proteins and other nucleic acids. Here, we used ribonucleoprotein immunoprecipitation (RIP) analysis to identify systematically the circRNAs associated with the cancer ...
Dimitrios Tsitsipatis +14 more
semanticscholar +1 more source
Role of P21 in Resistance of Lung Cancer
Chinese Journal of Lung Cancer, 2020 Lung cancer is the most common malignant tumor in the world with the highest incidence of deaths. In recent years, the treatment of lung cancer has made a significant breakthrough.
Tian FU, Ailing LIANG, Yongjun LIU
doaj +1 more source
Frontiers in Oncology, 2020 Abnormal histone deacetylase (HDAC) expression is closely related to cancer development and progression. Many HDAC inhibitors have been widely used in cancer treatment; however, severe side effects often limit their clinical application.
Chi-Yuan Chen +14 more
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The NUCKS1-SKP2-p21/p27 axis controls S phase entry
Nature Communications, 2021 Efficient entry into S phase of the cell cycle is necessary for embryonic development and tissue homoeostasis. However, unscheduled S phase entry triggers DNA damage and promotes oncogenesis, underlining the requirement for strict control.
Samuel Hume +6 more
semanticscholar +1 more source
Cancer Biology & Medicine, 2020 Objective: The E3 ligase, CRL4, plays diverse roles in different cellular processes, such as DNA damage, transcriptional regulation, cell cycle progression, and cell apoptosis.
Ting Li +6 more
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Cells, 2022 Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer, but it has nephrotoxic side effects leading to acute kidney injury and subsequently chronic kidney disease (CKD).
Jia-Bin Yu +3 more
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Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter [PDF]
, 2002 Although the promoters of both the Bax and p21 genes are activated by p53, they differ in the effect on this activation of the POU family transcription factor Brn-3a. Thus, Brn-3a inhibits activation of the Bax promoter by p53 but enhances the ability of
Budhram-Mahadeo, VS +2 more
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