Results 11 to 20 of about 162,345 (168)

The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27

Frontiers in Cell and Developmental Biology, 2020
The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding
Carmen Rodriguez-Cupello, Monica Dam, Laura Serini, Shan Wang, David Lindgren, Emelie Englund, Pontus Kjellman, Håkan Axelson, Alberto García-Mariscal, Chris D. Madsen   +9 more
doaj   +1 more source

MDM2 Antagonists Counteract Drug-Induced DNA Damage

EBioMedicine, 2017
Antagonists of MDM2-p53 interaction are emerging anti-cancer drugs utilized in clinical trials for malignancies that rarely mutate p53, including melanoma. We discovered that MDM2-p53 antagonists protect DNA from drug-induced damage in melanoma cells and
Anna E. Vilgelm, Priscilla Cobb, Kiran Malikayil, David Flaherty, C. Andrew Johnson, Dayanidhi Raman, Nabil Saleh, Brian Higgins, Brandon A. Vara, Jeffrey N. Johnston, Douglas B. Johnson, Mark C. Kelley, Sheau-Chiann Chen, Gregory D. Ayers, Ann Richmond   +14 more
doaj   +1 more source

Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21

FEBS Open Bio, 2022
Cholangiocarcinoma (CC) has a poor prognosis and different driver genes depending on the site of onset. Intrahepatic CC is the second‐most common liver cancer after hepatocellular carcinoma, and novel therapeutic targets are urgently needed.
Etsushi Kawamura, Tsutomu Matsubara, Atsuko Daikoku, Sanae Deguchi, Masahiko Kinoshita, Hideto Yuasa, Hayato Urushima, Naoshi Odagiri, Hiroyuki Motoyama, Kohei Kotani, Ritsuzo Kozuka, Atsushi Hagihara, Hideki Fujii, Sawako Uchida‐Kobayashi, Shogo Tanaka, Shigekazu Takemura, Keiko Iwaisako, Masaru Enomoto, Y. H. Taguchi, Akihiro Tamori, Shoji Kubo, Kazuo Ikeda, Norifumi Kawada   +22 more
doaj   +1 more source

Crude aqueous extracts of Pluchea indica (L.) Less. inhibit proliferation and migration of cancer cells through induction of p53-dependent cell death

BMC Complementary and Alternative Medicine, 2012
Background Pluchea indica (L.) Less. (Asteraceae) is a perennial shrub plant with anti-inflammatory and antioxidant medicinal properties. However, the anti-cancer properties of its aqueous extracts have not been studied.
Cho Jonathan J, Cho Chung-Lung, Kao Chiu-Li, Chen Chien-Ming, Tseng Chao-Neng, Lee Ya-Zhe, Liao Li-Jen, Hong Yi-Ren   +7 more
doaj   +1 more source

Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21

Molecular Therapy: Oncolytics, 2020
Radiotherapy with or without concurrent chemotherapy is the standard treatment for nasopharyngeal carcinoma (NPC) patients, whose efficacy is limited partly by intrinsic and acquired radioresistance. DNA methyltransferase 3B (DNMT3B) has been reported to
Cheng Wu, Ergang Guo, Jun Ming, Wei Sun, Xin Nie, Lu Sun, Shan Peng, Min Luo, Dongbo Liu, Linli Zhang, Qi Mei, Guoxian Long, Guangyuan Hu, Guoqing Hu   +13 more
doaj   +1 more source

PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Proteasome 26S subunit ATPase 2 (PSMC2) plays a pathogenic role in various cancers. However, its function and molecular mechanism in hepatocellular carcinoma (HCC) remain unknown.
Yiwei Liu, Yiwei Liu, Yiwei Liu, Hairong Chen, Xiangcheng Li, Xiangcheng Li, Xiangcheng Li, Feng Zhang, Feng Zhang, Feng Zhang, Lianbao Kong, Lianbao Kong, Lianbao Kong, Xuehao Wang, Xuehao Wang, Xuehao Wang, Jin Bai, Jin Bai, Xiaofeng Wu, Xiaofeng Wu, Xiaofeng Wu   +20 more
doaj   +1 more source

foxr1 is a novel maternal-effect gene in fish that is required for early embryonic success [PDF]

PeerJ, 2018
The family of forkhead box (Fox) transcription factors regulates gonadogenesis and embryogenesis, but the role of foxr1 in reproduction is unknown.
Caroline T. Cheung, Amélie Patinote, Yann Guiguen, Julien Bobe   +3 more
doaj   +2 more sources

Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate

Frontiers in Genetics, 2021
Thiamine (vitamin B1) is often deficient in oncopatients, particularly those undergoing chemotherapy. However, interaction between the thiamine deficiency and anticancer action of drugs has not been characterized.
Vasily A. Aleshin, Vasily A. Aleshin, Xiaoshan Zhou, Shuba Krishnan, Anna Karlsson, Victoria I. Bunik, Victoria I. Bunik, Victoria I. Bunik   +7 more
doaj   +1 more source

p21 in Cancer Research [PDF]

Cancers, 2019
p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity.
Shamloo, Bahar, Usluer, Sinem
openaire   +2 more sources

Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts

Biomolecules, 2019
NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under ethanol (
Sambantham Shanmugam, Dhyanesh Patel, John M. Wolpert, Caezaan Keshvani, Xiaobo Liu, Susan E. Bergeson, Srivatsan Kidambi, Lenin Mahimainathan, George I. Henderson, Madhusudhanan Narasimhan   +9 more
doaj   +1 more source