Results 21 to 30 of about 162,345 (168)
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: The intestinal epithelium must be resilient to physiochemical stress to uphold the physiological barrier separating the systemic compartment from the microbial and antigenic components of the gut lumen.
Alexandra A. Wolfarth +12 more
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ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53
mBio, 2019 Macrophages and dendritic cells dominate early immune responses to lentiviruses. HIV-1 sensing by pathogen recognition receptors induces signaling cascades that culminate in type I alpha/beta interferon (IFN-α/β) induction.
Edmund Osei Kuffour +4 more
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Antioxidants, 2020 Hericium erinaceus, a valuable pharmaceutical and edible mushroom, contains potent bioactive compounds such as H. erinaceus mycelium (HEM) and its derived ethanol extraction of erinacine A, which have been found to regulate physiological functions in our
Kam-Fai Lee +11 more
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Long noncoding RNA HOXC-AS3 interacts with CDK2 to promote proliferation in hepatocellular carcinoma
Biomarker Research, 2022 Background Hepatocellular carcinoma (HCC) is a type of cancer that affects the liver and has a high mortality rate. Long non-coding RNAs (lncRNAs) dysregulation can contribute to cancer occurrence and progression, although the underlying molecular ...
Chen Su +9 more
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Neoplasia: An International Journal for Oncology Research, 2007 Background: Osteopontin (OPN) is a secreted glycoprotein that mediates cell-matrix interactions and cellular signaling by binding with integrin (primarily αvβ3) and CD44 receptors.
Chengjiang Gao +3 more
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Kouqiang hemian waike zazhi[Objective:] To explore the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A/p21) in the healing process of tooth extraction wounds in diabetic mice and the effect on migration and polarization of macrophages.
ZHU Jiayu +5 more
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Biotechnology & Biotechnological Equipment, 2021 Multiple myeloma (MM) is the most common bone marrow malignancy which is defined with bone marrow infiltration of more than 10% of terminally differentiated plasma cells sive myeloma cells.
Jurijs Nazarovs +5 more
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Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence [PDF]
The EMBO Journal, 2002 The cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1/Sdi1) was identified initially as a gene induced in senescent cells and itself has been shown to cause permanent growth arrest/senescence. Reactive oxygen species (ROS), a byproduct of oxidative processes, can also induce an irreversible growth arrest similar to senescence. Here we show that p21
Macip, S. +6 more
openaire +3 more sources
rap1 p21 regulates the interaction of ras p21 with RGL, a new effector protein of ras p21 [PDF]
FEBS Letters, 1995 We have recently found that ralGDS family members (RGL and ralGDS) are putative effector proteins of ras p21. rap1 p21 is a small GTP‐binding protein which has the same amino acid sequence as the effector loop of ras p21. We examined the effect of rap1 p21 on the interaction of ras p21 with RGL.
Ikeda, Masahiro +4 more
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Veterinary Sciences, 2022 Due to the high incidence of mammary tumors in dogs, it is important to elucidate the pathogenesis of these tumors in veterinary medicine. Radiation therapy is often used to treat mammary tumors that target DNA lesions.
Kei Shimakawa +10 more
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