Results 111 to 120 of about 126,105 (250)
Journal of Advanced Nursing, EarlyView.ABSTRACT Aim To develop an in‐depth understanding of peoples' perceptions and experiences of decision‐making and reasons why they declined the opportunity of a kidney transplant. Design The Theory of Planned Behaviour informed the qualitative interpretative phenomenological analysis. Methods Semi‐structured interviews were conducted between August 2022
Emma Jones +3 more
wiley +1 more source
A variant of the Kochen-Specker theorem localising value indefiniteness
, 2015 The Kochen-Specker theorem proves the inability to assign, simultaneously, noncontextual definite values to all (of a finite set of) quantum mechanical observables in a consistent manner.
Abbott, Alastair A. +2 more
core +1 more source
Journal of Advanced Nursing, EarlyView.ABSTRACT Aims To explore how the restricted visitation policy impacts family members' visitation experiences and perceptions in an adult intensive care unit (ICU). Design Focused ethnography. Methods Data collection included 39 observation sessions (totalling 65.3 h), 19 semi‐structured interviews with family members, and document analysis of policies ...
Lian Zhu +3 more
wiley +1 more source
Kernel learning for ligand-based virtual screening: discovery of a new PPARgamma agonist [PDF]
, 2010 Poster presentation at 5th German Conference on Cheminformatics: 23. CIC-Workshop Goslar, Germany. 8-10 November 2009 We demonstrate the theoretical and practical application of modern kernel-based machine learning methods to ligand-based virtual ...
Hansen, Katja +9 more
core
Journal of Integrative Plant Biology, EarlyView.Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia +12 more
wiley +1 more source
The ZmRACK1–ZmCDPK7–ZmAPX1 module regulates plant antiviral immunity
Journal of Integrative Plant Biology, EarlyView.In maize, ZmRACK1 acts as a scaffold protein that bridges the cyclin‐dependent kinase ZmCDPK7 and the ascorbate peroxidase ZmAPX1, promoting ZmAPX1 activity to mitigate MCMV infection. Upon viral infection, P31 obstructs formation of the ZmRACK1‐ZmCDPK7‐ZmAPX1 complex, inhibiting ZmCDPK7‐mediated ZmAPX1 activity and promoting reactive oxygen species ...
Yuyang Zhang +13 more
wiley +1 more source
The prognostic value of altered eIF3a and its association with p27 in non-small cell lung cancers.
PLoS ONE, 2014 BackgroundOver-expressed eukaryotic initiation factor 3a (eIF3a) in non-small cell lung cancer (NSCLC) contributed to cisplatin sensitivity. However, the role of eIF3a in oncogenesis was still controversial.
Jie Shen +12 more
doaj +1 more source
PWO proteins are associated with PRC2 since their emergence in vascular plants
New Phytologist, EarlyView.Summary The Polycomb repressive complex 2 (PRC2), a conserved histone methyltransferase complex, plays a central role in transcriptional silencing across eukaryotes. Here, we investigate the evolution of PWWP‐DOMAIN INTERACTORS OF POLYCOMBS (PWOs), which interact with PRC2, and examine the conservation of the PWOs‐PRC2 interaction across plant ...
Ahamed Khan +11 more
wiley +1 more source
RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation
Photochemistry and Photobiology, EarlyView.UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract In this study, we investigated whether a structured aerobic exercise programme could enhance microRNA‐126 (miR‐126) expression and improve subclinical atherosclerosis markers [carotid intima–media thickness (CIMT) and ankle–brachial index (ABI)] in individuals with prediabetes.
Elif Yildirim Ayaz +9 more
wiley +1 more source