Results 121 to 130 of about 126,105 (250)

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

“I'm Not Here to Teach You How to Be Gay:” LGBTQ+ Client Experiences of Othering in Emotionally Focused Couple Therapy

Journal of Marital and Family Therapy, Volume 52, Issue 3, July 2026.
ABSTRACT Despite the increasing emphasis on addressing the intersections of client and therapist identity to improve therapeutic outcomes, therapy clients holding marginalized identities continue to experience othering. Othering is a process that engenders marginalization and inequality based on preconceived group identity, involves the hegemonic ...
Caitlin Edwards, Lekie Dwanyen, Andrea Wittenborn, Robert Allan   +3 more
wiley   +1 more source

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

NNMT/1‐MNA Promote Cell‐Cycle Progression of Breast Cancer by Targeting UBC12/Cullin‐1‐Mediated Degradation of P27 Proteins

Advanced Science
Cell cycle dysregulation is a defining feature of breast cancer. Here, 1‐methyl‐nicotinamide (1‐MNA), metabolite of nicotinamide N‐methyltransferase(NNMT) is identified, as a novel driver of cell‐cycle progression in breast cancer. NNMT, highly expressed
Yilei Ma, Xucheng Huang, Yanzhong Wang, Yinjiao Lei, Jinwei Yu, Shaobo Yu, Yuzhen Gao, Jun Yang, Feng Zhao, Haitao Yu, Jin Zeng, Yadong Chu, Min Yang, Guoli Li, Xinyou Xie, Jun Zhang   +15 more
doaj   +1 more source

Detection of MSI signals from peripheral blood for monitoring response to immune checkpoint blockade therapy in patients with advanced microsatellite‐unstable gastrointestinal cancers: A pilot study

International Journal of Cancer, Volume 158, Issue 12, Page 3312-3323, 15 June 2026.
What's new? A substantial proportion of patients with microsatellite‐unstable gastrointestinal adenocarcinomas do not benefit from immunotherapy. This study demonstrates that microsatellite instability can be reliably detected in plasma‐derived extracellular vesicle DNA from patients with microsatellite‐unstable gastrointestinal cancers.
Aysel Ahadova, Lena Bohaumilitzky, Thomas Walle, Joscha A. Kraske, Mirjam Tariverdian, Ulrike Ganserer‐Schmitt, Ingrid Hausser‐Siller, Vera Fuchs, Nina Nelius, Gizem Mehtap Erisen, Johannes Gebert, Albrecht Stenzinger, Dirk Jäger, Magnus von Knebel Doeberitz, Georg Martin Haag, Elena Busch, Matthias Kloor   +16 more
wiley   +1 more source

p27 and Skp2 immunoreactivity and its clinical significance with endocrine and chemo-endocrine treatments in node-negative early breast cancer [PDF]

, 2017
Background: Low p27 and high Skp2 immunoreactivity are associated with a poor prognosis and other poor prognostic features including resistant phenotypes and antiestrogen drug resistance.
Castiglione-Gertsch, M., Coates, A., Gianni, L., Goldhirsch, A., Gusterson, B. A., Maffini, F., Mastropasqua, M. G., Monti, F., Panzini, I., Price, K. N., Ravaioli, A., Regan, M. M., Spataro, V., Viale, G.   +13 more
core  

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. [PDF]

, 2018
Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC).
Addya, Sankar, Bhardwaj, Anshul, Birbe, Ruth, Chellappagounder, Thangavel, Den, Robert B., Dicker, Adam P., Ertel, Adam, Ettickan, Boopathi, Haber, Alex, Knudsen, Karen E., Liu, Yi, McNair, Christopher, Perepelyuk, Maryna, Salvino, Joseph M., Shoyele, Sunday   +14 more
core   +1 more source

Circular RNA TAF4B targeting MFN2 accelerates cell growth in bladder cancer through p27 depression and AKT activation

Frontiers in Immunology
IntroductionBladder cancer (BCa) is a common malignancy in the urinary tract. It has high recurrence rates and often requires microscopic examination, which presents significant challenges in clinical treatment.
Xiaoting Zhang, Jia Xu, Guangzhen Zhuang, Yiting Wang, Xiaofeng Li, Xiaohui Zhu   +5 more
doaj   +1 more source