Results 31 to 40 of about 47,767 (140)
PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest [PDF]
Cell Cycle, 2012 In this manuscript, we present experimental evidence that PKCs phosphorylate p27 at T198 in vitro and in vivo, resulting in p27 stabilization and cell cycle arrest in MCF-7 and HeLa cells. Our findings indicate that (1) recombinant PKCα, βII, δ, η and θ isoforms phosphorylate, in in vitro kinase assays, wild-type recombinant p27 protein expressed in E.
Fernanda, De Vita +5 more
openaire +2 more sources
The RSV F p27 peptide: current knowledge, important questions
Frontiers in Microbiology, 2023 Respiratory syncytial virus (RSV) remains a leading cause of hospitalizations and death for young children and adults over 65. The worldwide impact of RSV has prioritized the search for an RSV vaccine, with most targeting the critical fusion (F) protein.
Wanderson Rezende +5 more
doaj +1 more source
The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27
Frontiers in Cell and Developmental Biology, 2020 The STRIPAK complex has been linked to a variety of biological processes taking place during embryogenesis and development, but its role in cancer has only just started to be defined. Here, we expand on previous work indicating a role for the scaffolding
Carmen Rodriguez-Cupello +9 more
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The SKP2‐p27 axis defines susceptibility to cell death upon CHK1 inhibition
Molecular Oncology, 2022 Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under‐replicated DNA or exogenous DNA damage.
Michael Lohmüller +7 more
doaj +1 more source
BMC Biology, 2010 Background The cyclin-dependent kinase (CDK) inhibitor p27Kip1 is downregulated in a majority of human cancers due to ectopic proteolysis by the ubiquitin-proteasome pathway.
Lu Lifang +4 more
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Molecular Therapy: Nucleic Acids, 2020 Bone marrow (BM)-derived CD45 (BM45) cells were demonstrated to exhibit an improved antifibrotic effect on the treatment of CCL4-induced liver fibrosis by significantly increasing the level of matrix metalloproteinase 9 (MMP-9).
Xing Lu +9 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2008 Background p27Kip1 plays a major role as a negative regulator of the cell cycle. The regulation of p27Kip1 degradation is mediated by its specific ubiquitin ligase subunits S-phase kinase protein (Skp) 2 and cyclin-dependent kinase subunit (Cks) 1 ...
Wang Facheng +4 more
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Emerging Roles of SKP2 in Cancer Drug Resistance
Cells, 2021 More than half of all cancer patients receive chemotherapy, however, some of them easily acquire drug resistance. Resistance to chemotherapy has become a massive obstacle to achieve high rates of pathological complete response during cancer therapy.
Ting Wu, Xinsheng Gu, Hongmei Cui
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Clinicopathological Significance of Loss of p27 Expression in Papillary Thyroid Carcinoma
The International Journal of Biological Markers, 2017 Introduction A meta-analysis was done to investigate the clinicopathological significance of the loss of p27 kip1 expression in papillary thyroid carcinoma (PTC). Methods The meta-analysis involving 17 studies included 1,652 PTC and 328 benign cases. The
Nae Yu Kim +3 more
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Biochemistry and Biophysics Reports, 2016 Previous reports from our lab have shown that Skp2 is necessary for p27 degradation and cell cycle progression during adipocyte differentiation. Data presented here demonstrate that the anti-inflammatory, anti-obesity phytochemical curcumin blocked Skp2 ...
Bradley S. Ferguson +2 more
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