Results 41 to 50 of about 47,767 (140)
Are p27 and p21 Cytoplasmic Oncoproteins? [PDF]
Cell Cycle, 2002 By causing cytoplasmic mislocation of p27 and p21, the Akt oncogenic kinase functionally inactivates these nuclear tumor suppressor proteins. Is cytoplasmic localization of p27 and p21 simply equivalent to loss of their function or are new functions acquired in the cytoplasm? Indeed, several lines of evidence suggest that cytoplasmic p27 and p21 may be
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Brazilian Journal of Medical and Biological Research, 2019 Multiple myeloma (MM) is a malignant neoplasm of plasma, and exhibits several harmful effects including osteolytic injuries, hypercalcemia, and immune dysfunction. Many patients with MM succumb to the underlying malignancy.
Ying Yang +3 more
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Probing the role of nascent helicity in p27 function as a cell cycle regulator. [PDF]
PLoS ONE, 2012 p27 regulates the activity of Cdk complexes which are the principal governors of phase transitions during cell division. Members of the p27 family of proteins, which also includes p21 and p57, are called the Cip/Kip cyclin-dependent kinase regulators ...
Steve Otieno, Richard Kriwacki
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Mechanism of p27 Unfolding for CDK2 Reactivation [PDF]
Scientific Reports, 2016 AbstractCell-cycle regulatory protein, CDK2 is active when bound to its complementary partner protein, CyclinA or E. Recent discovery of the Kip/Cip family of proteins has indicated that the activity of CDK2 is also regulated by a member protein, p27. Although, the mechanism of CDK2 inhibition by p27 binding is known from crystal structure, little is ...
Soumya Lipsa Rath, Sanjib Senapati
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p27kip1 at the crossroad between actin and microtubule dynamics
Cell Division, 2019 The p27kip1 protein, mainly known as a negative regulator of cell proliferation, has also been involved in the control of other cellular processes, including the regulation of cytoskeleton dynamics.
Gian Luca Rampioni Vinciguerra +5 more
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Dependent capitalism and the middle-income trap in Europe na East Central Europe
International Journal of Management and Economics, 2018 The post-2008 slowdown in economic convergence by countries of east central Europe towards the level of western Europe is interpreted with the help of a concept of dependent capitalism.
Myant Martin
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Clinics, 2012 Multiple endocrine neoplasias are autosomal dominant disorders characterized by the occurrence of tumors in at least two endocrine glands. Two MEN syndromes have long been known and are well characterized: the MEN type 1 (MEN1) and type 2 (MEN2).
Natalia S. Pellegata
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BMC Ophthalmology, 2018 Backgound To identify and compare specific protein levels between overacting inferior oblique (IO) muscles in superior oblique (SO) palsy patients and normal IO muscles. Methods We obtained 20 IO muscle samples from SO palsy patients with IO overaction ≥
Yeon Woong Chung +2 more
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Long Non Coding RNA-UCA1 Contributes to Cardiomyocyte Apoptosis by Suppression of p27 Expression
Cellular Physiology and Biochemistry, 2015 Background/Aims: Urothelial carcinoma-associated 1 (UCA1) is a recently identified long non coding RNA (lncRNA). However, few studies have explored its role in cardiomyocytes after focal cardiac ischemia reperfusion injury (CIR).
Youbin Liu +7 more
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MicroRNA-203 Regulates Growth and Metastasis of Breast Cancer
Cellular Physiology and Biochemistry, 2015 Backgrounds/Aims: MicroRNAs (MiRNAs) control many biological events and play critical roles in the development of tumor. Among all miRNAs, miR203 has been recently shown to have an inhibitory effect on prostate cancer.
Shan Zhao +5 more
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