Results 31 to 40 of about 39,255 (248)

The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation [PDF]

, 2013
Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second ...
A MacKenzie, A Surprenant, AN Shemon, B Gu, BC Suh, BJ Gu, BJ Gu, BM Saunders, BS Khakh, BS Khakh, C Andrei, C Marques-da-Silva, C Sun, C Virginio, Chengqun Sun, CP Lai, D Leon, D Zink, DS Emmett, DS Samways, E Adinolfi, E Bulanova, F Bretschneider, F Rassendren, G Girolomoni, H Gunosewoyo, HJ Bradley, HM Costa-Junior, HZ Hu, JS Wiley, K Schroder, KA Hillman, L Gudipaty, L Stokes, LC Denlinger, LC Denlinger, LE Browne, LH Jiang, LH Jiang, M Li, M Li, Michelle E. Heid, ML Gavala, ML Smart, MT Miras-Portugal, P Marin-Garcia, P Pelegrin, P Pelegrin, Peter A. Keyel, Pierre Bobé, Q Li, R Sluyter, RA North, Russell D. Salter, S Chaumont, S Kracun, S Locovei, S Penuela, S Roger, SD Ohlendorff, SD Silberberg, SL Fernando, SL Fernando, T Kawate, T Sugiyama, TM Egan, V Petrilli, W Duckwitz, Y Shinozaki   +68 more
core   +3 more sources

Introduction and perspective, historical note

Frontiers in Cellular Neuroscience, 2013
P2 nucleotide receptors were proposed to consist of two subfamilies based on pharmacology in 1985, named P2X and P2Y receptors. Later, this was confirmed following cloning of the receptors for nucleotides and studies of transduction mechanisms in the ...
Geoffrey eBurnstock
doaj   +1 more source

Purinergic receptor mediated calcium signalling in urothelial cells [PDF]

, 2019
Non-neuronal ATP released from the urothelium in response to bladder stretch is a key modulator of bladder mechanosensation. Whilst non-neuronal ATP acts on the underlying bladder afferent nerves to facilitate sensation, there is also the potential for ...
Brierley, Stuart M, Chess-Williams, Russell, Grundy, David, Grundy, Luke, Sellers, Donna J   +4 more
core   +3 more sources

Bradykinin Contributes to Sympathetic and Pressor Responses Evoked by Activation of Skeletal Muscle Afferents P2X in Heart Failure

Cellular Physiology and Biochemistry, 2016
Background/Aims: Published data suggest that purinergic P2X receptors of muscle afferent nerves contribute to the enhanced sympathetic nervous activity (SNA) and blood pressure (BP) responses during static exercise in heart failure (HF).
Jihong Xing, Jianhua Li
doaj   +1 more source

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E, Craigie, Eilidh, Unwin, Robert J, Wildman, Scott S.P.   +3 more
core   +3 more sources

Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity

Molecular Pain, 2010
Background To evaluate whether P2X receptors are involved in responses to noxious pulp stimulation, the P2X3 and P2X2/3 receptor agonist α,β-methyleneATP (α,β-meATP) was applied to the molar tooth pulp and nocifensive behavior and extracellular-signal ...
Sessle Barry J, Koshikawa Noriaki, Sakagami Hiroshi, Suzuki Ikuko, Hu James W, Shimizu Kohei, Adachi Kazunori, Shinoda Masamichi, Miyamoto Makiko, Honda Kuniya, Iwata Koichi   +10 more
doaj   +1 more source

The role of the P2X₇ receptor in infectious diseases.

PLoS Pathogens, 2011
ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X₇ receptor, the expression of which is upregulated by pro-inflammatory cytokines.
Catherine M Miller, Nicola R Boulter, Stephen J Fuller, Alana M Zakrzewski, Michael P Lees, Bernadette M Saunders, James S Wiley, Nicholas C Smith   +7 more
doaj   +1 more source

Structure of P2X receptors [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011
AbstractP2X receptors are trimeric ion channels that open in response to extracellular ATP. The publication of the first X‐ray structure of a closed P2X receptor has confirmed many of the functional experiments carried out since the mid‐1990s and provides a point of reference for the molecular dissection of P2X receptor function.
openaire   +2 more sources

Pharmacology of P2X receptors [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011
AbstractP2X receptors are ligand‐gated cation channels that mediate many of the extracellular actions of adenosine 5′‐triphosphate (ATP). The genes encoding seven different P2X subunits, P2X1–7, have been cloned and when expressed alone all P2X subunits form functional receptors, except P2X6, which usually only assembles in a heteromeric form. Subunits
Nawazish-i-Husain Syed, Nawazish-i-Husain Syed, Charles Kennedy   +2 more
openaire   +2 more sources

Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a

Virology Journal, 2011
Hepatitis C virus (HCV) is a major health problem in developing countries including Pakistan. Chronic HCV infection results in progressive liver disease including fibrosis, cirrhosis, insulin resistance and eventually hepatocellular carcinoma (HCC ...
Fatima Kaneez, Butt Sadia, Mehmood Azra, Ashraf Javed, Idrees Muhammad, Manzoor Sobia, Akbar Haji, Rehaman Irshad U, Qadri Ishtiaq   +8 more
doaj   +1 more source