Results 71 to 80 of about 11,033 (176)
Experimental Physiology, Volume 111, Issue 3, Page 1524-1542, 1 March 2026.Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted +11 more
wiley +1 more source
BMC Neuroscience, 2007 Background Adrenal chromaffin cells mediate acute responses to stress through the release of epinephrine. Chromaffin cell function is regulated by several receptors, present both in adrenergic (AD) and noradrenergic (NA) cells.
Castro Enrique +3 more
doaj +1 more source
P2X receptor‐mediated synaptic transmission
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractActivation of postsynaptic P2X receptors, which occur in many synapses in the central nervous system, following vesicular adenosine triphosphate (ATP) released from presynaptic terminals contributes to the fast excitatory neurotransmission. Postsynaptic P2X receptors mediate fast excitatory postsynaptic currents in synapses located in various ...
Lalo, U. +3 more
openaire +1 more source
P2X1 receptors and the endothelium
Memorias do Instituto Oswaldo Cruz, 2005 Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families.
LS Harrington, JA Mitchell
doaj +1 more source
Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family
Frontiers in Cellular Neuroscience, 2019 P2X receptors are ATP-gated cations channels formed by the homo or hetero-trimeric association from the seven cloned subunits (P2X1-7). P2X receptors are widely distributed in different organs and cell types throughout the body including the nervous ...
Camille Blanchard +5 more
doaj +1 more source
Journal of Neuroinflammation, 2010 Background During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X7 receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide
Peluffo Hugo +4 more
doaj +1 more source
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractBone is a dynamic organ that from the early stages of development defines an organism's form and function and responds to the external environment, a process that continues as the organism grows and persists even once maturity is reached. The formation, growth, and integrity of bone are co‐ordinated and maintained throughout life via the finely
openaire +1 more source
Molecular Pain, 2009 Background The translocation of neuronal nitric oxide synthase (nNOS) from the cytosol to the membrane is functionally coupled to the activation of N-methyl-D-aspartate (NMDA) receptors at synapses.
Ohnishi Takayuki +2 more
doaj +1 more source
Purinergic Signaling in Mast Cell Degranulation and Asthma
Frontiers in Pharmacology, 2017 Mast cells are responsible for the majority of allergic conditions. It was originally thought that almost all allergic events were mediated directly only via the high-affinity immunoglobulin E receptors.
Zhan-Guo Gao, Kenneth A. Jacobson
doaj +1 more source
The role of extracellular ATP and P2X receptors in the pathogenesis of HIV-1. [PDF]
Curr Opin Pharmacol, 2023 Rodriguez NR +3 more
europepmc +1 more source