Results 91 to 100 of about 21,110 (244)
Emerging key roles for P2X receptors in the kidney [PDF]
, 2013 P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E. +3 more
core +2 more sources
British Journal of Pharmacology, Volume 183, Issue 2, Page 296-312, January 2026.Background and Purpose Neuroinflammation is increasingly recognised to contribute to drug‐resistant epilepsy. Activation of ATP‐gated P2X7 receptors has emerged as an important upstream mechanism, and increased P2X7 receptor expression is present in the seizure focus in rodent models and patients. Pharmacological antagonists of P2X7 receptors attenuate
Jaideep Kesavan +6 more
wiley +1 more source
Functional Compartmentation of Endothelial P2Y Receptor Signaling [PDF]
Circulation Research, 2002 The presence of multiple receptors for disparate nucleotides on endothelial cells makes it unclear how the endothelium differentiates among these signals. We propose that endothelial P2Y receptors are organized into cholesterol-rich signaling domains, such as caveolae and respond to nucleotide agonists by mobilizing intracellular calcium.
Robert A, Kaiser +3 more
openaire +2 more sources
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Cell Proliferation, Volume 59, Issue 1, January 2026.Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng +4 more
wiley +1 more source
Physiological Electrical Signals Promote Chain Migration of Neuroblasts by Up-Regulating P2Y1 Purinergic Receptors and Enhancing Cell Adhesion [PDF]
, 2014 Acknowledgments This work was supported by a grant from NHS Grampian. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
Cao, Lin +4 more
core +2 more sources
The Journal of Physiology, Volume 604, Issue 1, Page 379-394, 1 January 2026.Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera +8 more
wiley +1 more source
Expression analysis of G Protein-coupled receptors in mouse macrophages [PDF]
, 2008 Background. Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity.
Glass, Christopher K. +10 more
core +4 more sources
The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells [PDF]
, 2013 Background: Nebivolol is a third-generation beta-blocker used to treat hypertension. The vasodilation properties of nebivolol have been attributed to nitric oxide (NO) release.
Corbalan, J Jose +5 more
core +1 more source
Advanced Biology, Volume 9, Issue 12, December 2025.Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams +7 more
wiley +1 more source
BMC Research Notes, 2010 Background Purines such as adenosine and ATP are now generally recognized as the regulators of many physiological functions, such as neurotransmission, pain, cardiac function, and immune responses.
Suzuki Tokiko +2 more
doaj +1 more source