Results 111 to 120 of about 25,694 (216)
p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction
, 2001 The neuronal cyclin-dependent kinase p35/cdk5 comprises a catalytic subunit (cdk5) and an activator subunit (p35). To identify novel p35/cdk5 substrates, we utilized the yeast two-hybrid system to screen for human p35 binding partners.
Brownlees, J +7 more
core +1 more source
Recombinant p35 from bacteria forms biologically active IL-12.
, 2014 (A) Refolded p35bac and p35bac/C92A were subjected to size exclusion chromatography. Monomeric protein was separated from multimeric assemblies on a Superdex 75 10/300 GL equilibrated in 50 mM Tris-HCl (pH 8.0) containing 250 mM NaCl.
Jens M. Moll (540876) +10 more
core +1 more source
The Journal of biological chemistry, 2003 Apoptosis is a highly regulated multistep process for programmed cellular destruction. It is centered on the activation of a group of intracellular cysteine proteases known as caspases. The baculoviral p35 protein effectively blocks apoptosis through its broad spectrum caspase inhibition.
Guozhou, Xu +6 more
openaire +1 more source
Regulation of N-cadherin-mediated adhesion by the p35–Cdk5 kinase
, 2000 Background: The p35–Cdk5 kinase has been implicated in a variety of functions in the central nervous system (CNS), including axon outgrowth, axon guidance, fasciculation, and neuronal migration during cortical development.
Gupta, Amitabh +4 more
core +1 more source
Protein-protein interactions involving the N-terminus of p35
, 2008 As a major regulator of Cdk5, the protein p35 exerts various effects on neuronal cells. Under certain conditions, p35 undergoes truncation of its N-terminus to form the protein p25.
Qi, Robert Z. +2 more
core
Subcellular localization of p35 or its mutants in Neuro2A cells.
, 2015 p35, wt, A108V or L302I, were coexpressed with knCDK5 in Neuro2A cells. Neuro2A cells were immunostained with an anti-myc antibody for p35 (green) and anti-CDK5 (red) at 24 h after transfection. Merges are shown in right panels. The blue signals indicate
Shunsuke Takada (338027) +5 more
core +1 more source
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
, 2001 Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in brain development and neuronal migration. Cdk5 is abundant in postmitotic, terminally differentiated neurons.
Bronson, R T +13 more
core +1 more source
, 2016 Cyclin-dependent kinase 5 (Cdk5) is activated by binding to its activators, p35 and p39. The level of Cdk5 activity is determined by the amount of p35 and p39, which is regulated not only by transcription but also via proteasomal degradation ...
Taro Saito (358910) +5 more
core +1 more source
The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein
, 2011 The neuronal Cdk5 activator p35 is involved in a multitude of neuronal activities, including cytoskeletal organization. We show here that p35 directly interacts with filamentous actin (F-actin) but not with monomeric actin (G-actin). Through binding, p35
He, LS (15541619) +5 more
core
The Protein SET Binds the Neuronal Cdk5 Activator p35 and Modulates Cdk5/p35 Activity [PDF]
Journal of Biological Chemistry, 2002 Dianbo Qu +6 more
openaire +1 more source