Results 121 to 130 of about 76,399 (242)

Cell and Gene Therapy in Equine Ocular Disease

open access: yesVeterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young   +2 more
wiley   +1 more source

CDK5: Key Regulator of Apoptosis and Cell Survival

open access: yesBiomedicines, 2019
The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The activation of CDK5 is dependent on interaction with its activator p35,
Rabih Roufayel, Nimer Murshid
doaj   +1 more source

Double solids, categories and non-rationality

open access: yes, 2013
This paper suggests a new approach to questions of rationality of threefolds based on category theory. Following M. Ballard, D. Favero, L. Katzarkov (ArXiv:1012.0864) and D. Favero, L.
Iliev, Atanas   +2 more
core   +1 more source

Exploring Medicines Optimisation and Safety in the Community Following Mental Health Hospital Discharge: A Qualitative Interview Study

open access: yesHealth Expectations, Volume 29, Issue 1, February 2026.
ABSTRACT Background Medication safety issues may be common following mental health hospital discharge. However, there is little research exploring their aetiology and influencing factors for patients with mental illness and their carers in the community.
Mark Jeffries   +5 more
wiley   +1 more source

Exploring Nurses' Decision‐Making Through the Lens of Capability: A Framework for Understanding Autonomy in Complex Care Environments

open access: yesJournal of Advanced Nursing, Volume 82, Issue 2, Page 1614-1627, February 2026.
ABSTRACT Aim To apply the capability approach to understand ICU nurses’ decision‐making autonomy. Design A qualitative study using Amartya Sen’s capability approach as a conceptual framework. Methods This study reanalyzed qualitative data from a previous investigation involving semi‐structured interviews with 39 experienced Canadian ICU nurses who ...
Patrick Lavoie
wiley   +1 more source

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

open access: yesGenes & Development, 1996
Cyclin-dependent kinase 5(cdk5) is highly homologous to other members of the cdk family that are known to function in proliferating cells. Despite the structural similarity, cdk5-associated histone H1 kinase activity is only detectable in postmitotic ...
M. Nikolic   +4 more
semanticscholar   +1 more source

Korean Red Ginseng protects dopaminergic neurons by suppressing the cleavage of p35 to p25 in a Parkinson's disease mouse model

open access: yesJournal of Ginseng Research, 2015
Background: Ginseng is known to have antiapoptotic, anti-inflammatory, and antioxidant effects. The present study investigated a possible role of Korean Red Ginseng (KRG) in suppressing dopaminergic neuronal cell death and the cleavage of p35 to p25 in ...
Ye Lee Jun   +4 more
doaj   +1 more source

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

open access: yesThe FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay   +7 more
wiley   +1 more source

Experimental Line Parameters of the b^(1)Σ^(+)_g ← X^(3)Σ^(-)_g Band of Oxygen Isotopologues at 760 nm Using Frequency-Stabilized Cavity Ring-Down Spectroscopy [PDF]

open access: yes, 2009
Positions, intensities, self-broadened widths, and collisional narrowing coefficients of the oxygen isotopologues ^(16)O^(18)O, ^(16)O^(17)O, ^(17)O^(18)O, and ^(18)O^(18)O have been measured for the b^(1)Σg + ← X^(3)Σg − (0,0) band using frequency ...
Brown, Linda R.   +7 more
core  

Retinal S-antigen Th1 cell epitope mapping in patients with Behcet's disease [PDF]

open access: yes
Background - Retinal S-antigen (S-Ag) is a most characterized autoantigen of autoimmune uveitis. The recognized immunodominant epitope of human S-Ag in patients with uveitis has not been identified. In this study, we selected certain patients with active
Du, L.P.   +6 more
core   +2 more sources

Home - About - Disclaimer - Privacy