Results 181 to 190 of about 67,493 (202)
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Callosal axon guidance defects in p35?/? mice
The Journal of Comparative Neurology, 1999Mice lacking p35, an activator of cdk5 in the central nervous system (CNS), exhibit defects in a variety of CNS structures, most prominently characterized by a disruption in the laminar structure of the neocortex (Chae et al., 1997). In addition, alterations of certain axonal fiber tracts are found in the cortex of p35 mutant mice.
Y T, Kwon, L H, Tsai, J E, Crandall
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ANKRA2 interacts with p35 and is a substrate for Cdk5/p35
2014Cdk5 is a serine/threonine kinase that plays a pivotal role in neural development. Activation of Cdk5 requires its association with its activator, p35 or p39. More than forty proteins have been identified as the substrates for Cdk5. By phosphorylating these diverse cellular targets, Cdk5 plays a multifunctional role in nervous system including neurite ...
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Peripeti
Peripeti 35 © Peripeti og forfatterne Temaredaktion Solveig Gade, Johan Holm Mortensen, Storm Møller Madsen, Anika Marschall, Thomas Rosen dal Nielsen. Redaktion Janicke Branth, Erik Exe Christoffersen, Solveig Daugaard, Michael Eigtved, Solveig Gade, Falk Heinrich, Storm Møller Madsen, Johan Holm Mortensen, Thomas Rosendal Nielsen (ansv ...
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Peripeti 35 © Peripeti og forfatterne Temaredaktion Solveig Gade, Johan Holm Mortensen, Storm Møller Madsen, Anika Marschall, Thomas Rosen dal Nielsen. Redaktion Janicke Branth, Erik Exe Christoffersen, Solveig Daugaard, Michael Eigtved, Solveig Gade, Falk Heinrich, Storm Møller Madsen, Johan Holm Mortensen, Thomas Rosendal Nielsen (ansv ...
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Molecular Brain Research, 2002
Cyclin-dependent kinase 5 (cdk5) is involved in the development of the nervous system and neuronal process outgrowth, and it regulates several intracellular processes including cytoskeletal dynamics. Dysregulation of cdk5 has been implicated in many disorders of the nervous system.
Petri, Kerokoski +4 more
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Cyclin-dependent kinase 5 (cdk5) is involved in the development of the nervous system and neuronal process outgrowth, and it regulates several intracellular processes including cytoskeletal dynamics. Dysregulation of cdk5 has been implicated in many disorders of the nervous system.
Petri, Kerokoski +4 more
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Activity and regulation of p35 / Cdk5 kinase complex
2000Publisher Summary This chapter discusses the activity and regulation of p35/Cdk5 kinase complex. The importance of the p35/Cdk5 kinase in cortical development has been shown by mouse knockout experiments. In neurons, both p35 and Cdk5 localize to the actin-rich peripheral lamellipodia of growing axons.
M, Nikolic, L H, Tsai
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