Results 101 to 110 of about 321,034 (216)

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

GLUT2 regulation of p38 MAPK isoform protein expression and p38 phosphorylation in male versus female rat hypothalamic primary astrocyte Cultures

IBRO Neuroscience Reports
Recent studies documented regulation of hypothalamic astrocyte mitogen-activated protein kinase (MAPK) pathways, including p38, by the plasma membrane glucose carrier/sensor glucose transporter-2 (GLUT2). Sex-specific GLUT2 control of p38 phosphorylation
Madhu Babu Pasula, Paul W. Sylvester, Karen P. Briski   +2 more
doaj   +1 more source

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN. [PDF]

, 1999
A
Ballard, Bandres, Barnes, Bergmann, Beyaert, Boldin, Cao, Carpentier, Chen, Chu, Cooper, Darnay, DeLamarter, De Valck, De Valck, Dignam, Dixit, Eckner, Ferran, Fukushi, Geleziunas, Gerritsen, Harris, Henkel, Heyninck, Hsu, Hsu, Hsu, Hu, Ishida, Ishida, Jäättelä, Kelliher, Krikos, Laherty, Laherty, LeBail, Lee, Malinin, Mercurio, Min, Muzio, Natoli, Naumann, Ng, Niederman, Niwa, Opipari, Perkins, Plaisance, Reinhard, Sarma, Schreck, Semmes, Song, Southern, Uhlik, Van Antwerp, Vandenabeele, Vanden Berghe, W., S. Plaisance, E. Boone, K. De Bosscher, M.L. Schmitz, W. Fiers, and G. Haegeman, Vanhaesebroeck, Van Snick, Vincenz, Yeh, Yin, Yurochko, Zandi, Zhang, Zhong, Zhong   +69 more
core   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

CD133-containing microvesicles promote colorectal cancer progression by inducing tumor angiogenesis

Heliyon
Angiogenesis is an indispensable mechanism in cancer progression, as cancer cells need to establish blood vessels to supply oxygen and nutrients. Extracellular vesicles (EVs) derived from cancer cells act as messengers in the tumor microenvironment and ...
Beomsu Kim, Suhyun Kim, Sungyeon Park, Jesang Ko   +3 more
doaj   +1 more source

Synthesis, characterization and pharmacological evaluation of pyrazolyl urea derivatives as potential anti-inflammatory agents

Acta Pharmaceutica Sinica B, 2017
p38α mitogen activated protein kinase (MAPK) inhibitors provide a novel approach for the treatment of inflammatory disorders. A series of fifteen pyrazolyl urea derivatives (3ao) were synthesized and evaluated for their p38α MAPK inhibition and ...
Kanagasabai Somakala, Mohammad Amir
doaj   +1 more source

Disruption of Interleukin-1β Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function [PDF]

, 2014
Patients with cystic fibrosis (CF) have elevated concentration of cytokines in sputum and a general inflammatory condition. In addition, CF cells in culture produce diverse cytokines in excess, including IL-1B. We have previously shown that IL-1B, at low
Clauzure, Mariangeles, Massip Copiz, María Macarena, Schulman, Gustavo, Teiber, Maria Luz, Tomás A. Santa-Coloma, Valdivieso, Ángel Gabriel   +5 more
core   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

MiR-497-5p regulates ox-LDL-induced dysfunction in vascular endothelial cells by targeting VEGFA/p38/MAPK pathway in atherosclerosis

Heliyon
Background: The impairment of endothelial cells triggered by oxidized low-density lipoprotein (ox-LDL) stands as a critical event in the advancement of atherosclerosis (AS).
Wei Lu, Guoqing Wan, He Zhu, Tao Zhu, Xinmei Zhang   +4 more
doaj   +1 more source

Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation

Molecules, 2017
Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products.
You Chul Chung, Seoyeon Kim, Jin Hwa Kim, Geun Soo Lee, Jung No Lee, Nam Ho Lee, Chang-Gu Hyun   +6 more
doaj   +1 more source