Results 191 to 200 of about 321,034 (216)
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Benzimidazolone p38 inhibitors
Bioorganic & Medicinal Chemistry Letters, 2004The synthesis and in vitro p38 alpha activity of a novel series of benzimidazolone inhibitors is described. The p38 alpha SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38 alpha in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors ...
Mark A, Dombroski +17 more
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p38 activation and viral infection
Expert Reviews in Molecular Medicine, 2022AbstractViruses completely rely on the energy and metabolic systems of host cells for life activities. Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no specific clinical vaccines or drugs against most viral infections. Therefore, understanding the molecular and cellular mechanisms of viral infections is
Luyao, Wang +7 more
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Journal of Nutrition Education and Behavior, 2007
S. Yeluri, N. Muthukumar, N.J. London
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S. Yeluri, N. Muthukumar, N.J. London
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p38 MAPK regulates COPII recruitment
Biochemical and Biophysical Research Communications, 2007Here, we investigate regulation of coat protein complex II (COPII) recruitment onto ER export sites in permeabilized cells. In cytosols from nocodazole treated HeLa cells we find COPII loading is inhibited. The stress kinase p38 MAPK is activated in these cytosols and COPII loading can be rescued by depletion of p38 MAPK alpha or by the p38 MAPK ...
Wang, Lijun, Lucocq, John M.
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