SnapShot: p38 MAPK Substrates [PDF]
Cell, 2013 p38α mitogen-activated protein kinase (MAPK14) phosphorylates many downstream substrates, which allows this pathway to regulate a wide variety of cellular processes, including growth, proliferation, or differentiation. All p38α-mediated phosphorylations have been reported to occur on Ser or Thr residues, which are usually followed by a Pro residue ...
Natalia Trempolec +2 more
openaire +2 more sources
CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway
Journal of Experimental & Clinical Cancer Research, 2019 Background Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria.
Mansi Babbar +3 more
doaj +1 more source
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
core +2 more sources
Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]
, 2015 A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding +8 more
core +1 more source
WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]
, 2015 Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T +6 more
core +1 more source
Frontiers in PharmacologyBackgroudCaowu (CW, Aconitum kusnezoffii Reichb.) is a well-known Mongolian medicine with the effects of dispelling cold and relieving pain. In China, it is widely used in the prevention and treatment of rheumatoid arthritis (RA).
Jing Wang +8 more
doaj +1 more source
Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation [PDF]
, 2003 Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their transforming potential are still not fully understood.
Gutkind, J. Silvio +4 more
core +1 more source
Frontiers in Oncology, 2019 Background and purpose: Angiogenesis and lymphangiogenesis are major routes for metastatic spread of tumor cells. It thus represent the rational targets for therapeutic intervention of cancer.
Shiu-Wen Huang +11 more
doaj +1 more source
Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Bogoyevitch +13 more
core +1 more source
Frontiers in Immunology, 2019 Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However,
Lijun Dong +18 more
doaj +1 more source