Results 201 to 210 of about 177,903 (366)

Mitogen-Activated Protein (MAP) Kinases Are Involved in Interleukin-1 (IL-1)-Induced IL-6 Synthesis in Osteoblasts: Modulation Not of p38 MAP Kinase, But of p42/p44 MAP Kinase by IL-1-Activated Protein Kinase C [PDF]

, 1999
M. Miwa
openalex   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

Cancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo, Jingchuan He, Xiaoju Shen, Changsheng Li, Xiaoxiang Mo, Kai Liang, Liangjun He, Tingting Li, Xiaoqin Pan, Sisi Cao, Naiquan Mao, Shangping Xing, Zhiquan Chen, Zhuo Luo, Jie Yang   +14 more
wiley   +1 more source

Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

International Journal of Nanomedicine, 2015
Soo-Jin Choi, Hee-Jeong Paek, Jin YuDepartment of Food Science and Technology, Seoul Women’s University, Seoul, Republic of KoreaAbstract: Anionic nanoclays are layered double hydroxide nanoparticles (LDH-NPs) that have been shown to exhibit ...
Choi SJ, Paek HJ, Yu J
doaj  

Lysophosphatidylcholine Activates p38 and p42/44 Mitogen-Activated Protein Kinases in Monocytic THP-1 Cells, but Only p38 Activation Is Involved in Its Stimulated Chemotaxis [PDF]

, 2000
Qing Jing, Sun-Mei Xin, Wen-Bo Zhang, Ping Wang, Yong-Wen Qin, Gang Pei   +5 more
openalex   +1 more source

Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression

Cancer Science, EarlyView.
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu, Yuka Itoh, Tomoe Sawaguchi, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa   +6 more
wiley   +1 more source

Circulating Levels of VEGF, mTOR and MAPK in Patients With Port-Wine Stains. [PDF]

J Cosmet Dermatol
ABSTRACT Background Vascular endothelial growth factor (VEGF), mammalian target of rapamycin (mTOR) and mitogen‐activated protein kinase (MAPK) pathways play important roles in the pathogenesis of port‐wine stains (PWS). However, reports on circulating levels of VEGF, mTOR, and MAPK in PWS patients are rare.
Huang Y, Wu P, Yang J, Bi M, Cao L, Wang L.   +5 more
europepmc   +2 more sources

ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. [PDF]

, 2015
Backgrounds and aims4-6 million people die of enteric infections each year. After invading intestinal epithelial cells, enteric bacteria encounter phagocytes.
Casanova, James E, Castillo, Victoria, Choudhury, Sarmistha Sinha, Das, Soumita, Eckmann, Lars, Elliott, Michael R, Ernst, Peter B, Fox, Sarah, Owen, Katherine A, Sarkar, Arup   +9 more
core  

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway

, 1999
Pavel Kovarik, Dagmar Stoiber, Patrick A. Eyers, Rossella Menghini, Armin Neininger, Matthias Gaestel, Philip Cohen, Thomas Decker   +7 more
openalex   +1 more source

p38 Mitogen-activated Protein Kinase Mediates Bid Cleavage, Mitochondrial Dysfunction, and Caspase-3 Activation during Apoptosis Induced by Singlet Oxygen but Not by Hydrogen Peroxide [PDF]

, 2000
Shougang Zhuang, John Demirs, Irene E. Kochevar   +2 more
openalex   +1 more source

TGF‐β Enhances Doxorubicin Resistance and Anchorage‐Independent Growth in Cancer Cells by Inducing ALDH1A1 Expression

Cancer Science, EarlyView.
We have demonstrated that prestimulation of human lung cancer cells with TGF‐β enhances resistance to doxorubicin‐induced growth inhibition, depending on Smad3 and Smad4 through induction of ALDH1A1. Knockdown of ALDH1A1 suppressed TGF‐β‐induced resistance to doxorubicin, and exogenous expression of ALDH1A1 in SMAD3‐KO cells restored the drug ...
Takashi Yokoyama, Masao Saitoh, Keiji Miyazawa   +2 more
wiley   +1 more source