Results 271 to 280 of about 100,277 (305)

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Science, 2002
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another.
Gary L, Johnson, Razvan, Lapadat
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p38 mitogen-activated protein kinase and pain

Life Sciences, 2020
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain.
Lijia, Mai, Xiao, Zhu, Fang, Huang, Hongwen, He, Wenguo, Fan   +4 more
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p38 Mitogen-Activated Protein Kinase Regulates Myelination

Journal of Molecular Neuroscience, 2007
The p38 mitogen-activated protein kinase family is emerging as a crucial signaling molecule for a vast number of cellular functions including cell migration, proliferation, and differentiation. The function of p38 in myelination has only been recently addressed.
Jeffery D, Haines, Gabriela, Fragoso, Shireen, Hossain, Walter E, Mushynski, Guillermina, Almazan   +4 more
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p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

Mini-Reviews in Medicinal Chemistry, 2006
The importance of p38 MAPK inhibitors as new drug for rheumatoid arthritis is reflected by the large number of compounds that has been developed over the last years. In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed.
J, Westra, P C, Limburg
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Role of p38 Mitogen-Activated Protein Kinase in Thrombus Formation

Journal of Receptors and Signal Transduction, 2004
The present study was designed to elucidate the role of p38 mitogen-activated protein kinase (p38) in thrombus formation. We used p38alpha heterozygous (p38alpha+/-) mice and used ferric chloride (FeCl3)-induced carotid artery injury as a model of thrombus formation.
Kanako, Sakurai, Yuji, Matsuo, Tatsuhiko, Sudo, Yoh, Takuwa, Sadao, Kimura, Yoshitoshi, Kasuya   +5 more
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Mitogen-Activated Protein Kinase p38 Pathway in Venous Ulcer Fibroblasts

Vascular and Endovascular Surgery, 2008
Objective: Venous ulcer fibroblasts (w-fb) have attenuated growth compared to normal fibroblasts (n-fb). The MAPKp38 pathway mediates stress-responses in various diseases. We hypothesize that p38 pathway is altered in w-fb. Methods: W-fb were isolated from venous ulcers and n-fb from the ipsilateral thigh.
Joseph D, Raffetto, Christopher H, Gram, Kristen C, Overman, James O, Menzoian   +3 more
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p38 Mitogen-Activated Protein Kinase Inhibitors— Mechanisms and Therapeutic Potentials

Pharmacology & Therapeutics, 1999
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be selective inhibitors for p38 mitogen-activated protein kinase (MAPK), a member of the MAPK family.
J C, Lee, S, Kassis, S, Kumar, A, Badger, J L, Adams   +4 more
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Analyzing JNK and p38 mitogen-activated protein kinase activity

2001
Publisher Summary The JNK and p38 mitogen-activated protein (MAP) kinase groups are important for many physiological processes including cell growth, oncogenic transformation, cell differentiation, apoptosis, and the immune response. To understand the role of JNK and p38 MAP kinases in the cell, several protocols for measuring their activation state ...
Whitmarsh, A. J., Davis, R. J.
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Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2005
Dehydroepiandrosterone-sulfate, the sulfated form of dehydroepiandrosterone, is the most abundant steroid in young adults, but gradually declines with aging. In humans, the clinical application of dehydroepiandrosterone targeting some collagen diseases, such as systemic lupus erythematosus, as an adjunctive treatment has been applied in clinical trial.
Kenji, Ashida, Kiminobu, Goto, Yue, Zhao, Taijiro, Okabe, Toshihiko, Yanase, Ryoichi, Takayanagi, Masatoshi, Nomura, Hajime, Nawata   +7 more
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Inhibitors of p38 Mitogen-Activated Protein Kinase

BioDrugs, 2003
Asthma is an inflammatory disease of the airways, which in patients with mild to moderate symptoms is adequately controlled by either beta(2)-adrenoceptor agonists or corticosteroids, or a combination of both. Despite this, there are classes of patients that fail to respond to these treatments.
Robert, Newton, Neil, Holden
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