Results 281 to 290 of about 100,277 (305)

Structure-Activity Relationships of p38 Mitogen-Activated Protein Kinase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2005
Rheumatoid arthritis and other chronic inflammatory diseases constitute a major therapeutic challenge, usually not sufficiently met by the classical antiinflammatory medications. Recent research efforts provided new insights into the molecular basis of these pathologies and disclosed new opportunities for developing improved drugs directed to the ...
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p38 Mitogen-Activated Protein Kinase Pathways in Asthma and COPD

Chest, 2011
The mitogen-activated protein kinase (MAPK) family includes the p38 kinases, which consist of highly conserved proline-directed serine-threonine protein kinases that are activated in response to inflammatory signals. Of the four isoforms, p38α is the most abundant in inflammatory cells and has been the most studied through mainly the availability of ...
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Activation of p38 Mitogen-activated Protein Kinase in Rat Periapical Lesions

Journal of Endodontics, 2008
The purpose of this study was to investigate the activation of p38 mitogen-activated protein kinase (MAPK) during the development of periapical lesions in rats. Periapical lesions developed within 28 days after pulp exposure of mandibular first molars in Wistar rats.
Rui, Zhang, Li, Wang, Bin, Peng
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Effectors—Sonic Hedgehog and p38 Mitogen-Activated Protein Kinase

2008
This chapter covers the identification of mitogen-activated protein kinases as early stage transducers of the damaging effects of glucose on peripheral nerves. They are activated by several metabolic consequences of hyperglycemia, in particular oxidative stress, osmotic stress, and advanced glycation end products.
Sally A. Price, Rebecca C. Burnand, David R. Tomlinson   +2 more
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Assays for JNK and p38 Mitogen-Activated Protein Kinases

2000
T, Sudo, M, Karin
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The many paths to p38 mitogen-activated protein kinase activation in the immune system

Nature Reviews Immunology, 2006
Jonathan D Ashwell
exaly  

Mitogen-activated protein kinases in innate immunity

Nature Reviews Immunology, 2013
J Simon C Arthur, Steven C Ley
exaly  

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

Nature Reviews Drug Discovery, 2003
Sanjay Kumar
exaly  

Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial

Lancet, The, 2014
L Kristin Newby, Michael S. Marber, Philip Eg Aylward   +2 more
exaly  

Mixed-lineage kinase control of JNK and p38 MAPK pathways

Nature Reviews Molecular Cell Biology, 2002
Kathleen Gallo
exaly