Results 1 to 10 of about 3,933 (119)

Characterization of patient-derived HPV16 E6 and E7 variant alleles [PDF]

Journal of Virology
Human papillomavirus type 16 (HPV16) is the most prevalent carcinogenic HPV type. Many HPV16 sequence variants have been described, some of which cause protein-coding mutations.
Miranda Grace, Harshita Beeravolu, Ahmad Alhamshari, Josipa Skelin, Si-Young Kiessling, Andrew Bohm, Elizabeth A. White, Karl Munger   +7 more
doaj   +2 more sources

Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations. [PDF]

Health Sci Rep
ABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Beygnejad F, Eslami N, Nejad KG, Kermanshahi AZ, Baghi HB.   +4 more
europepmc   +2 more sources

The R2TP complex stabilises E7 to drive human papillomavirus-mediated pathogenesis in cellular models of cervical cancer [PDF]

Virology Journal
Human papillomaviruses (HPVs), particularly types 16 and 18, are major contributors to cervical cancer through the oncogenic activities of the E6 and E7 proteins.
Mahaiwon Shadang, Aruna Arumugam, Dhiraj Kumar Singh, Pankaj Keshari, Sandeep Mathur, Venkateswaran K. Iyer, Seema Singhal, Shyam S. Chauhan, Qulsum Akhter, Riyaz Ahmad Mir   +9 more
doaj   +2 more sources

mRNA-encoded mutant HPV16/18 vaccines promote specific T-cell responses and synergize with anti-PD-1 checkpoint blockade in mediating therapeutic tumor regression in mice [PDF]

Journal for ImmunoTherapy of Cancer
Background Persistent infection with high-risk human papillomavirus (HPV) 16 and 18 is a major driver of human cancer, including head and neck and cervical cancers. Although prophylactic vaccines prevent infection, effective therapies for established HPV-
Lei Li, Wei Xu, Qiang Zhang, Ying Zhang, Dong Xu, Xue Qiao, Hongya Han, Ya Zhou, Yongchao Zhao, Xiaoju Zhang, Shaoli Liu, Andong Liu, Xiaoyun Ma, Beibei Cao, Chenxing Ni, Hongxiaoying Yu, Lushuai Jin, Jianqi Zhang   +17 more
doaj   +2 more sources

Molecular, immunological and oncogenic mechanisms of cervical cancer mediated by HPV/HIV co-infection, clinical implication and management [PDF]

Infectious Agents and Cancer
Human papillomavirus (HPV) and human immunodeficiency virus (HIV) co-infection pose a major public health challenge, especially in regions with high HIV prevalence.
Swase Dominic Terkimbi, Ugwu Okechukwu Paul-Chima, Regan Mujinya, Chebet Joan, Philippe E.P. Mounmbegna, Michael Ben Okon, Anyanwu Godson Emeka, Solomon Adomi Mbina, Anyanwu Chinyere Nkemjika, Patrick Maduabuchi Aja   +9 more
doaj   +2 more sources

E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence. [PDF]

PLoS Pathogens
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The formation of a trimeric complex between the HPV E6 oncoprotein, the cellular ubiquitin ligase E6AP and the p53 tumor suppressor protein leads to proteolytic p53 degradation
Alicia Avenhaus, Milica Velimirović, Julia Bulkescher, Martin Scheffner, Felix Hoppe-Seyler, Karin Hoppe-Seyler   +5 more
doaj   +2 more sources

Transcriptome analysis of HPV16-positive cells expressing intrabodies targeting E6 and E7 oncoproteins to unravel intrabody antitumor activity [PDF]

Journal of Translational Medicine
Background Human Papillomavirus-associated cancer remains a global health issue despite the availability of prophylactic vaccination. Two single-chain recombinant antibodies specific for the high-risk HPV16-E6 and E7 oncoproteins were previously ...
Susanna Falcucci, Sabrina Tait, Maria Vincenza Chiantore, Anna Rita Ciccaglione, Carla Amici, Paola Di Bonito, Luisa Accardi   +6 more
doaj   +2 more sources

PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications

Biology, 2023
High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific ...
Francisco Aguayo, Francisco Perez-Dominguez, Julio C. Osorio, Carolina Oliva, Gloria M. Calaf   +4 more
doaj   +1 more source

Metabolic Reprogramming in Cancer: Role of HPV 16 Variants

Pathogens, 2021
Metabolic reprogramming is considered one of the hallmarks in cancer and is characterized by increased glycolysis and lactate production, even in the presence of oxygen, which leads the cancer cells to a process called “aerobic glycolysis” or “Warburg ...
Adán Arizmendi-Izazaga, Napoleón Navarro-Tito, Hilda Jiménez-Wences, Miguel A. Mendoza-Catalán, Dinorah N. Martínez-Carrillo, Ana E. Zacapala-Gómez, Monserrat Olea-Flores, Roberto Dircio-Maldonado, Francisco I. Torres-Rojas, Diana G. Soto-Flores, Berenice Illades-Aguiar, Julio Ortiz-Ortiz   +11 more
doaj   +1 more source

Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins

mSphere, 2020
The beta human papillomaviruses (HPVs) are subdivided into 5 species (beta-1 to beta-5), and they were first identified in the skin. However, the beta-3 species appears to be more highly represented in the mucosal epithelia than in the skin.
Lucia Minoni, Maria Carmen Romero-Medina, Assunta Venuti, Cécilia Sirand, Alexis Robitaille, Gennaro Altamura, Florence Le Calvez-Kelm, Daniele Viarisio, Katia Zanier, Martin Müller, Rosita Accardi, Massimo Tommasino   +11 more
doaj   +3 more sources