Results 21 to 30 of about 3,933 (119)

A Comprehensive Discussion in Vaginal Cancer Based on Mechanisms, Treatments, Risk Factors and Prevention

Frontiers in Oncology, 2022
Vaginal cancer is a rare and uncommon disease that is rarely discussed. Although vaginal cancer traditionally occurs in older postmenopausal women, the incidence of high-risk human papillomavirus (HPV)-induced cancers is increasing in younger women ...
Sumit Kumar Baral, Partha Biswas, Partha Biswas, Md. Abu Kaium, Md. Aminul Islam, Dipta Dey, Md Al Saber, Tanjim Ishraq Rahaman, A. M, Talha Bin Emran, Talha Bin Emran, Md. Nazmul Hasan, Mi-Kyung Jeong, Ihn Han, Md. Ataur Rahman, Md. Ataur Rahman, Md. Ataur Rahman, Bonglee Kim, Bonglee Kim   +18 more
doaj   +1 more source

Molecular and genetic profile of head and neck squamous cell carcinoma

Медицинский вестник Юга России, 2018
To determine the molecular pathways of head and neck squamous cell carcinoma (HNSCC) tumorogenesis there are held a great amount of investigations. New therapeutic models for HNSCC are discussed considering genetic and biochemical specifications and ...
A. I. Stukan, V. A. Porhanov, V. N. Bodnya, O. Yu. Chuhraj, Y. M. Makarova, I. S. Elizbaryan   +5 more
doaj   +1 more source

Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities

Frontiers in Molecular Biosciences, 2022
Cervical cancer is a Human Papilloma virus-related disease, which is on the rise in a number of countries, globally. Two essential oncogenes, E6 and E7, drive cell transformation and cancer development.
Lilian Makgoo, Salerwe Mosebi, Zukile Mbita   +2 more
doaj   +1 more source

The E7 protein of the cottontail rabbit papillomavirus immortalizes normal rabbit keratinocytes and reduces pRb levels, while E6 cooperates in immortalization but neither degrades p53 nor binds E6AP

Virology, 2008
Human papillomaviruses (HPVs) cause cervical cancer and are associated with the development of non-melanoma skin cancer. A suitable animal model for papillomavirus-associated skin carcinogenesis is the infection of domestic rabbits with the cottontail rabbit papillomavirus (CRPV).
Ganzenmueller, Tina, Matthaei, Markus, Muench, Peter, Scheible, Michael, Iftner, Angelika, Hiller, Thomas, Leiprecht, Natalie, Probst, Sonja, Stubenrauch, Frank, Iftner, Thomas   +9 more
openaire   +2 more sources

Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway

Scientific Reports, 2017
High risk human papilloma viruses cause several types of cancer. The HPV oncoproteins E6 and E7 are essential for oncogenic cell transformation. E6 mediates the degradation of the tumor suppressor p53, and E7 can form complexes with the retinoblastoma ...
Martin Fischer, Sigrid Uxa, Clara Stanko, Thomas M. Magin, Kurt Engeland   +4 more
doaj   +1 more source

Proapoptotic activities of Oroxylum indicum leave extract in HeLa cells

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To examine the proapoptotic properties of Oroxylum indicum methanol extract on cervical cancer cells. Methods: Methylene blue assay was used to determine the IC50 value of the extract.
Nurul Hidayah Wahab, Nur Afina Mohd Din, Yee Ying Lim, Noor Izani Noor Jamil, Nor Fazila Che Mat   +4 more
doaj   +1 more source

Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly

BMC Cancer, 2019
Background Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC).
Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong, Paul K. S. Chan   +6 more
doaj   +1 more source

Persistent human papillomavirus infection in the etiology of cervical carcinoma: The role of immunological, genetic, viral and cellular factors [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2014
The aim of this paper was to present the role of human papillomavirus (HPV) in cervical carcinogenesis from several aspects. By explaining the HPV virus lifecycle and structure, its effect on cervical cell cycle and subversion of immune response
Živadinović Radomir, Petrić Aleksandra, Lilić Goran, Lilić Vekoslav, Đorđević Biljana   +4 more
doaj   +1 more source

In silico Structural Prediction of E6 and E7 Proteins of Human Papillomavirus Strains by Comparative Modeling [PDF]

International Journal Bioautomation, 2012
More than 200 different types of Human papillomavirus (HPV) are identified, 40 transmit extensively through sexual contacts affecting the genital tract. HPV strains have been etiologically linked to vaginal, vulvar, penile, anal, oral and cervical cancer
Satish Kumar, Lingaraja Jena, Vidya W. Bhomale, Sangeeta Daf   +3 more
doaj  

Low frequency of p53 mutations in cervical carcinomas among Brazilian women

Brazilian Journal of Medical and Biological Research, 2001
Human papillomavirus (HPV) infections of the high-risk types are strongly linked to the development of cervical carcinoma. The HPV oncoproteins E6 and E7 are thought to play a crucial role in this process through their interactions with the p53 protein ...
N.A. Pinheiro, L.L. Villa
doaj   +1 more source