Results 11 to 20 of about 3,933 (119)

HPV18 E6/E7 Mutation and Their Association with The Expression Level of Tumor Suppressor Proteins p53 and pRb among Indonesian Women with Cervical Cancer

Indonesian Biomedical Journal
BACKGROUND: The E6/E7 mutation contributes to the intra-typic variant of HPV18 which may differ in their oncogenic potential. E6 and E7 target the tumour suppressor protein p53 and pRb, respectively, and their degradation play a crucial role in cervical ...
I Nyoman Bayu Mahendra, Pande Kadek Aditya Prayudi, Ida Bagus Nyoman Putra Dwija   +2 more
doaj   +2 more sources

The comparison of curcumin and nanocurcumin effects on the expression of E6 and E7 human papilloma virus oncogenes and P53 and pRb factors in HeLa and fibroblast cell lines [PDF]

, 2021
Abstract Cervical cancer is a common cancer in women around the world. Human papillomavirus infection is main cause of this cancer. Currently treatment methods include chemotherapy, radiation therapy and surgery. These methods usually cause severe reactions and drug resistance in the patients, so finding a safe natural drug for treatment can be
Rezvaneh Vahedian Sadeghi, Masoud Parsania, Majid Sadeghizadeh, Setareh Haghighat, Seyedeh Sahar Mortazavi Farsani   +4 more
openaire   +1 more source

Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions [PDF]

Journal of Virology, 1994
The transforming genes E6 and E7 of high-risk human papillomaviruses are consistently expressed in papillomavirus-associated neoplasms of the anogenital tract. In papillomavirus type 18-associated SW 756 cervical carcinoma cells, transcription of the viral E6-E7 genes is blocked by dexamethasone. Herein we show that dexamethasone-mediated repression of
M, von Knebel Doeberitz, C, Rittmüller, F, Aengeneyndt, P, Jansen-Dürr, D, Spitkovsky   +4 more
openaire   +2 more sources

Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control [PDF]

Oncogene, 2002
We have identified parameters which define a causal role of HPV16 in head and neck cancer. Twenty-eight tumours which were typed positive for HPV16 DNA, were comprehensively analysed for expression of the viral oncogenes E6 and E7, the status of the p53 gene, and the protein status of pRb and p16(INK4a).
Tina, Wiest, Elisabeth, Schwarz, Christel, Enders, Christa, Flechtenmacher, Franz X, Bosch   +4 more
openaire   +2 more sources

Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis. [PDF]

PLoS ONE, 2013
Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor constitutively active and aberrantly expressed in cervical cancer.
Shirish Shukla, Sutapa Mahata, Gauri Shishodia, Arvind Pandey, Abhishek Tyagi, Kanchan Vishnoi, Seemi F Basir, Bhudev C Das, Alok C Bharti   +8 more
doaj   +1 more source

Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease

Viruses, 2023
Anal cancer is a major health problem. This study seeks to determine if the topical protease inhibitor Saquinavir (SQV), is effective at the prevention of anal cancer in transgenic mice with established anal dysplasia. K14E6/E7 mice were entered into the
Laura C. Gunder, Hillary R. Johnson, Evan Yao, Tyra H. Moyer, Heather A. Green, Nathan Sherer, Wei Zhang, Evie H. Carchman   +7 more
doaj   +1 more source

Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

Virology Journal, 2021
Background Approximately 15% of human cancers are attributed to viruses. Numerous studies have shown that high-risk human polyomaviruses (HR-HPV) and Merkel cell polyomavirus (MCPyV) are two human tumor viruses associated with anogenetal and ...
Kashif Rasheed, Baldur Sveinbjørnsson, Ugo Moens   +2 more
doaj   +1 more source

The Detection of Complexed Proteins E6/P53 and E7/Prb In Relation to Carcinogenesis of the Uterine Cervix [PDF]

Journal of Cytology & Histology, 2014
Objective: The aim of our work was to identify by Western Blot technique (WB) the oncoproteins generated by E6 and E7 genes of high risk Human Papillomavirus (HR-HPV), resulting from integration of viral genomes into cervical cell DNA and their interactions with tumor suppressor human proteins p53 and pRb in premalignant or malignant cervical lesions.
openaire   +1 more source

Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF.

PLoS ONE, 2014
High-risk human papillomavirus oncoproteins E6 and E7 play a major role in HPV-related cancers. One of the main functions of E7 is the degradation of pRb, while E6 promotes the degradation of p53, inactivating the p14ARF-p53 pathway.
Isabelle Dichamp, Paule Séité, Gérard Agius, Alice Barbarin, Agnès Beby-Defaux   +4 more
doaj   +1 more source

Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response

Virology Journal, 2018
Background Despite vaccination and screening measures, anogenital cancer, mainly promoted by HPV16 oncoproteins, still represents the fourth tumor and the second cause of death among women.
Diletta Francesca Squarzanti, Rita Sorrentino, Manuela Miriam Landini, Andrea Chiesa, Sabrina Pinato, Francesca Rocchio, Martina Mattii, Lorenza Penengo, Barbara Azzimonti   +8 more
doaj   +1 more source