Results 1 to 10 of about 101,614 (324)

Rapid activation of p62 body-mediated autophagy in human cells under hyperosmotic stress [PDF]

Communications Biology
The autophagy receptor p62 is degraded via autophagy under hyperosmotic stress, but whether this involves the formation of biomolecular condensates (p62 bodies) remains unclear.
Naoki Tamura, Satoshi Waguri
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p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases [PDF]

Brain Sciences, 2020
Turnover of the mitochondrial pool due to coordinated processes of mitochondrial biogenesis and mitophagy is an important process in maintaining mitochondrial stability. An important role in this process is played by the Nrf2/ARE signaling pathway, which
Artem P. Gureev, Irina S. Sadovnikova, Natalia N. Starkov, Anatoly A. Starkov, Vasily N. Popov   +4 more
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p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet

Frontiers in Physiology, 2022
Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non ...
Ikuru Miura, Kosuke Okada, Akiko Ishii, Eiji Warabi, Takahisa Watahiki, Keii To, Hitoshi Shimano, Shunichi Ariizumi, Junichi Shoda   +8 more
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p62 Promotes Malignancy of Hepatocellular Carcinoma by Regulating the Secretion of Exosomes and the Localization of β-Catenin

Frontiers in Bioscience-Landmark, 2022
Background: p62 is a multi-domain protein and participates in a variety of cellular biological activities. p62 is also related to tumor malignancy. However, the underlying molecular mechanism of p62 regulating the progression of hepatocellular carcinoma (
Weibang Yang, Jinxing Wei, Lihong Lv, Jiyan Xie, Ang Li, Zhihua Zheng, Wenfeng Zhuo, Peiqing Liu, Jun Min   +8 more
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‘High vault-age’: non-coding RNA control of autophagy [PDF]

Open Biology, 2020
RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the
Magdalena Büscher, Rastislav Horos, Matthias W. Hentze   +2 more
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Prevention of non‐alcoholic steatohepatitis by long‐term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice

Physiological Reports, 2021
Exercise ameliorates nonalcoholic fatty liver disease (NAFLD) by inducing phenotypic changes in Kupffer cells (KCs). p62/Sqstm1‐knockout (p62‐KO) mice develop NAFLD alongside hyperphagia‐induced obesity. We evaluated (1) the effects of long‐term exercise
Ikuru Miura, Shoichi Komine, Kosuke Okada, Shota Wada, Eiji Warabi, Fumihiko Uchida, Sechang Oh, Hideo Suzuki, Yuji Mizokami, Junichi Shoda   +9 more
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Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis

Cell Death and Disease, 2021
p62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling.
Lifeng Feng, Miaoqin Chen, Yiling Li, Muchun Li, Shiman Hu, Bingluo Zhou, Liyuan Zhu, Lei Yu, Qiyin Zhou, Linghui Tan, Huimin An, Xian Wang, Hongchuan Jin   +12 more
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Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy

Cell & Bioscience, 2023
Background Macro-autophagy/Autophagy is an evolutionarily well-conserved recycling process to maintain the balance through precise spatiotemporal regulation.
Qin Xia, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Liqun Liu, Lei Dong   +6 more
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Measurement of Autophagy Activity Reveals Time-Dependent, Bacteria-Specific Turnover during Mycobacterium tuberculosis Infection

Pathogens, 2022
The intracellular pathogen, Mycobacterium tuberculosis (M. tb) uses various mechanisms to evade its killing. One of such is phagosomal damage and cytosolic translocation which is then targeted by the host’s bactericidal autophagy pathway. It is suggested
Naomi Okugbeni, André du Toit, Victoria Cole-Holman, Glynis Johnson, Ben Loos, Craig Kinnear   +5 more
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The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

Biomedicines, 2021
p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key ...
Paulina Hennig, Gabriele Fenini, Michela Di Filippo, Tugay Karakaya, Hans-Dietmar Beer   +4 more
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