Results 121 to 130 of about 101,614 (324)

P62. VISUAL PERCEPTIONS OF HEMIFACIAL MICROSOMIA RECONSTRUCTION: A PROSPECTIVE STUDY WITH EYE TRACKING TECHNOLOGY AND LINEAR MIXED EFFECTS MODEL ANALYSIS

, 2022
Dillan F. Villavisanis, Clifford I. Workman, Zachary D. Zapatero, Giap H. Vu, Jessica D. Blum, Liana Cheung, Daniel Cho, Jordan W. Swanson, Scott P. Bartlett, Anjan Chatterjee, Jesse A. Taylor   +10 more
openalex   +1 more source

P62: An emerging oncotarget for osteolytic metastasis

Journal of Bone Oncology, 2016
Bone metastasis occurs in the majority of late-stage tumors with poor prognosis. It is mainly classified as osteoblastic metastasis and osteolytic metastasis. The pathogenesis of osteolytic metastasis is a "vicious cycle" between tumor cells and bone cells (primarily the osteoclasts), which is mediated by secretory factors. The P62 adapter protein is a
Jing Zhang, Zuozhang Yang, Jian Dong
openaire   +3 more sources

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer [PDF]

, 2022
Qing Shi, Xiaofeng Jin, Pingzhao Zhang, Qian Li, Zeheng Lv, Yan Ding, Huiying He, Yijun Wang, Yuanlong He, Xiaying Zhao, Shi-Min Zhao, Yao Li, Kun Gao, Chenji Wang   +13 more
openalex   +1 more source

BCR-ABL/p62/SQSTM1: a cannibal embrace [PDF]

Blood, 2012
In this issue of Blood, Goussetis et al identify autophagy as a new pathway for the degradation of the oncoprotein BCR-ABL. They show that the therapeutic drug arsenic trioxide (AS(2)O(3)) targets BCR-ABL for autophagic degradation via a p62/SQSTM1-dependent mechanism that is critical for the antileukemic effect of the drug.
openaire   +2 more sources

Multifunctional H2S‐activated metal‐organic framework systems for targeted colorectal cancer imaging and synergistic copper‐induced tumor regression

BMEMat, EarlyView.
The in situ reaction of Cu‐MOFs with endogenous H2S enabled PA imaging and facilitated combined PTT/chemotherapy for colorectal cancer therapy. Abstract Stimuli‐responsive nanomaterials offer significant potential for enhancing diagnostic accuracy, optimizing therapeutic efficacy, and advancing precision theranostics.
Nannan Zheng, Qinghui Wang, Zhiyue Cao, Chao Yu, Renkai Zhang, Kaiyan Xiang, Haoguang Wu, Kai Li, Qianqian Ni, Qiuyue Ma, Jing Mu, Xiaoyuan Chen, Liangcan He, Shaoqin Liu   +13 more
wiley   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

A two‐sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy

Epilepsia Open, EarlyView.
Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun, Di Ma, Wuqiong Zhang, Shuai Hou, Zhiqing Chen, Xuewei Li, Hongmei Meng, Daguang Zhang   +7 more
wiley   +1 more source

ACOD1, rather than itaconate, facilitates p62‐mediated activation of Nrf2 in microglia post spinal cord contusion

Clinical and Translational Medicine
Background Spinal cord injury (SCI)‐induced neuroinflammation and oxidative stress (OS) are crucial events causing neurological dysfunction. Aconitate decarboxylase 1 (ACOD1) and its metabolite itaconate (Ita) inhibit inflammation and OS by promoting ...
Zhanyang Qian, Mingjie Xia, Tianyu Zhao, You Li, Guangshen Li, Yanan Zhang, Haijun Li, Lei Yang   +7 more
doaj   +1 more source

mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney

Frontiers in Immunology
Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues that form de novo in nonlymphoid organs. In this study, we demonstrate that the kidneys of aged mice with a renal tubule-specific knockout of autophagy-related 7 (Atg7) contain numerous and ...
Daniel J. Atwood, Zhibin He, Makoto Miyazaki, Katharina Hopp, Alkesh Jani, Seth B. Furgeson, Sarah Faubel, Charles L. Edelstein, Charles L. Edelstein   +8 more
doaj   +1 more source