Results 131 to 140 of about 101,614 (324)

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

Food Frontiers, EarlyView.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu, Jiating Li, Yonghui Dong, Jia Li, Ji Bian, Chao Liu, Hongbo Zhang, Lin Han, Min Wang   +8 more
wiley   +1 more source

Formation of high molecular weight p62 by CORM-3.

PLoS ONE, 2019
CORM-3 is a water-soluble carbon monoxide (CO)-releasing molecule developed for possible therapeutic use of CO. CORM-3 belongs to a group of metal carbonyl compounds that contain transition metals and carbonyls as the central scaffold and coordinated ...
Toshihiko Aki, Kana Unuma, Kanako Noritake, Naho Hirayama, Takeshi Funakoshi, Koichi Uemura   +5 more
doaj   +1 more source

Cardiomyocyte‐Derived USP20 Attenuates Diabetic Cardiomyopathy by Facilitating the Degradation of STING and Mitigating STING‐Mediated Inflammation [PDF]

FASEB J
USP20 directly binds to STING and promotes the degradation of STING through the autophagy pathway by deubiquitinating p62 via its active site C154, thereby alleviating myocardial inflammation and improving ventricular remodeling and heart failure induced by diabetes. ABSTRACT Although extensive clinical and basic research has been conducted on diabetic
Zhou Y, Ying M, Qi B, Chen Y, Lin W, Zhang C, Lin J, Zhang Y, Yang Z, Huang Z, Wu J, Cai X, Huang W, Huang Z, Cheng Z, Dai S.   +15 more
europepmc   +2 more sources

Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: Involvement of autophagy and p21/Nrf2 axis

Scientific Reports, 2017
Adiponectin possesses potent anti-inflammatory properties. p62, an adaptor protein composed of multi-functional domain, is known to play a role in controlling inflammatory responses.
Nirmala Tilija Pun, Pil-Hoon Park
doaj   +1 more source

P62 The impact of area deprivation on engagement in arts and cultural activities: evidence from a UK nationally-representative study [PDF]

, 2020
Hei Wan Mak, Rory Coulter, Daisy Fancourt   +2 more
openalex   +1 more source

Sequestration of translation initiation factors in p62 condensates [PDF]

, 2023
Alberto Danieli, Georg Vucak, Manuela Baccarini, Sascha Martens   +3 more
openalex   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Autophagy Alterations in White and Brown Adipose Tissues of Mice Exercised under Different Training Protocols

Frontiers in Bioscience-Landmark
Background: Autophagy is a conserved catabolic process that promotes cellular homeostasis and health. Although exercise is a well-established inducer of this pathway, little is known about the effects of different types of training ...
Isaac Tamargo-Gómez, Manuel Fernández-Sanjurjo, Helena Codina-Martínez, Cristina Tomás-Zapico, Eduardo Iglesias-Gutiérrez, Benjamín Fernández-García, Álvaro F. Fernández   +6 more
doaj   +1 more source

Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response [PDF]

, 2016
Yanan Wang, Wei‐Guo Zhu, Ying Zhao
openalex   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source