Results 141 to 150 of about 101,614 (324)

Usutu virus NS4A induces autophagy and is targeted by the selective autophagy receptor p62/SQSTM1 for degradation

Virology Journal
Usutu virus (USUV) is an emerging orthoflavivirus, which mainly affects birds but in rare cases can cause severe neuroinvasive disease in humans. The virus relies on a multitude of host cell proteins, molecules and cellular processes for its replication,
Tessa Nelemans, Ali Tas, Nina L. de Beijer, George M. C. Janssen, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert   +6 more
doaj   +1 more source

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy [PDF]

, 2013
Jae Myung Park, Shengbing Huang, Tsung‐Teh Wu, Nathan R. Foster, Frank A. Sinicrope   +4 more
openalex   +1 more source

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. [PDF]

, 2014
Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise when dysregulated.
Batlevi, Yakup, Carromeu, Cassiano, Cortes, Constanza J, Frankowski, Harald, Garden, Gwenn A, Ivanov, Nishi, La Spada, Albert R, Le, Amy, Miranda, Helen C, Muotri, Alysson R, Sopher, Bryce L, Young, Jessica E   +11 more
core  

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source

Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery [PDF]

, 2012
Basant Abdulrahman, Arwa Abu Khweek, Anwari Akhter, Kyle Caution, Mia Tazi, Hoda Hassan, Yucheng Zhang, Patrick D. Rowland, Sankalp Malhotra, Famke Aeffner, Ian C. Davis, Miguel A. Valvano, Amal O. Amer   +12 more
openalex   +1 more source

Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. [PDF]

, 2017
Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master metabolic kinase AMPK enhances autophagy. Here we report that cyclin D1 restrains autophagy by
Bisetto, Sara, Casimiro, Mathew C., Di Rocco, Agnese, Disante, Gabriele, Jiao, Xuanmao, Kusminski, Christine M., Li, Zhiping, Loro, Emanuele, Ly, Daniel, Pestell, Richard, Pestell, Timothy G., Pupo, Claudia, Scherer, Philipp E., Seifert, Erin L., Shen, Che-Hung, Velasco-Velázquez, Marco A., Wang, Chenguang, Zheng, Bin   +17 more
core   +1 more source

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

Enriched Environment Enhances Motor Function in Mice With Cerebral Infarction by Promoting mTOR‐Dependent Autophagy in the Contralateral Dentate Nucleus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Although environmental enrichment (EE) promotes post‐stroke motor recovery, the mechanisms underlying its regulation of cerebellar dentate nucleus (DN) plasticity remain unclear; this study therefore investigated how EE coordinates autophagy, mitochondrial homeostasis, and synaptic remodeling in the contralateral DN to facilitate functional ...
Chuan‐Jie Wang, Ke‐Wei Yu, Jun‐Fa Wu, Feng Tao   +3 more
wiley   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source