Results 151 to 160 of about 101,614 (324)

Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity

open access: yesJournal of Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) infections often trigger oxidative stress and cytokine storms, resulting in significant tissue damage that causes fatalities in piglets and reproductive issues in sows.
Fang Wang   +13 more
doaj   +1 more source

Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged Mice

open access: gold, 2023
Hui Qian   +9 more
openalex   +1 more source

The Human p62 cDNA Encodes Sam68 and Not the RasGAP-Associated p62 Protein [PDF]

open access: yesCell, 1996
Lock, Peter   +4 more
openaire   +2 more sources

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik   +3 more
wiley   +1 more source

Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes   +6 more
wiley   +1 more source

稳定过表达外源p62/SQSTM1基因的U937白血病细胞株的建立及初步特性分析

open access: yesZhongshan Daxue xuebao. Yixue kexue ban, 2015
摘 要: 【目的】 构建稳定过表达外源p62/SQSTM1基因的人急性单核细胞白血病U937细胞株,并初步分析过表达p62基因对U937细胞的影响?【方法】 首先在空载体MSCV-IRES-GFP(MIG)基础上构建重组质粒MSCV-p62-IRES-GFP(MPIG),分别用MIG及MPIG载体进行病毒包装,并感染U937细胞,用流式细胞分选仪分选出绿色荧光细胞,获得U937-GFP和U937-p62稳定细胞株,利用流式细胞仪及Western blot分别检测GFP细胞的阳性率及p62蛋白表达水平 ...
doaj  

P62/Ubiquitin IHC Expression Correlated with Clinicopathologic Parameters and Outcome in Gastrointestinal Carcinomas [PDF]

open access: gold, 2015
Amr Mohamed   +6 more
openalex   +1 more source

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

open access: yes, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte   +3 more
wiley   +1 more source

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