Results 181 to 190 of about 101,614 (324)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

IL‐1β Induces p62/SQSTM1 and Represses Androgen Receptor Expression in Prostate Cancer Cells

, 2014
Megan Chang, Viral Patel, Michael Gwede, Micaela Morgado, Kelly M. Tomasevich, Eliza Li Shan Fong, Mary C. Farach‐Carson, Nikkí A. Delk   +7 more
openalex   +2 more sources

Author response: miRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling

, 2022
Shumin Wang, Eri O. Maruyama, John Martinez, Justin Lopes, Trunee Hsu, Wencheng Wu, Wei Hsu, Takamitsu Maruyama   +7 more
openalex   +1 more source

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases

The FEBS Journal, EarlyView.
Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu, Noemi Nagy, Carlos Mario Ayala‐Torres, Maria G. Masucci   +3 more
wiley   +1 more source

Systematic Screening of Ubiquitin/p62 Aggregates in Cerebellar Cortex Expands the Neuropathological Phenotype of the C9orf72 Expansion Mutation

, 2018
Oscar Ramos‐Campoy, Rainiero Ávila-Polo, Oriol Grau‐Rivera, Anna Antonell, Jordi Clarimón, Ricardo Rojas-García, Sara Charif, Veronica Santiago-Valera, Isabel de la Torre Díez, Miquel Aguilar, Consuelo Almenar, Dolores López‐Villegas, Lorena Bajo Peñas, Pau Pástor, Julie van der Zee, Albert Lladó, Raquel Sánchez‐Valle, Ellen Gelpí   +17 more
openalex   +2 more sources

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62 [PDF]

, 2015
Li-Chun Lisa Tsai, Lei Xie, Kim Doré, Li Xie, Jason C. Del Rio, Charles C. King, Guillermo Martinez‐Ariza, Christopher Hulme, Roberto Malinow, Philip E. Bourne, Alexandra C. Newton   +10 more
openalex   +1 more source

Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes [PDF]

, 2020
Masaki Kobayashi, Hiromine Yasukawa, Tomoya Arikawa, Yusuke Deguchi, Natsumi Mizushima, Misako Sakurai, Shoichi Onishi, Ryoma Tagawa, Yuka Sudo, Naoyuki Okita, Kyohei Higashi, Yoshikazu Higami   +11 more
openalex   +1 more source

Regulating SQSTM1/P62 and Wnt/β-catenin signaling of EMT to constrain TNBC  invasiveness. [PDF]

, 2022
Rajib Shome, Plaboni Sen, Siddhartha Sankar Ghosh   +2 more
openalex   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, EarlyView.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

Assessing inconsistencies in the FITradeoff method: a comparison of two preference modeling paradigms

International Transactions in Operational Research, EarlyView.
Abstract Many decision‐making processes are susceptible to errors and inconsistencies introduced by decision‐makers (DMs). The development of decision support systems (DSS) has brought about a way to guide DMs through complex decision scenarios. However, due to the complexity of the process, inconsistencies may still arise.
Evanielle Barbosa Ferreira, Lucia Reis Peixoto Roselli, Adiel Teixeira de Almeida   +2 more
wiley   +1 more source