Results 11 to 20 of about 101,614 (324)

Tissue specific induction of p62/sqstm1 by farnesoid X receptor [PDF]

, 2012
Background: Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis. FXR is protective against carcinogenesis and inflammation in
Ann M. Thomas, Bo Kong, Grace L. Guo, Guodong Li, Jean-Marc A. Lobaccaro, Jessica A. Williams, Le Zhan, Wen Xie, Wen-Xing Ding, Yuka Inaba   +9 more
core   +7 more sources

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

Molecular Cell, 2023
p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how autophagosomes efficiently sequester p62 droplets.
Xue Huang, Jia Yao, Lu Liu, Jing Chen, Ligang Mei, Jingjing Huangfu, Dong Luo, Xinyi Wang, Changhai Lin, Xiaorong Chen, Yi Yang, Sheng Ouyang, Fujing Wei, Zhuolin Wang, Shaolin Zhang, Tingxiu Xiang, Dante Neculai, Qiming Sun, Eryan Kong, Edward W. Tate, Aimin Yang   +20 more
openaire   +4 more sources

p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4)

Cells, 2020
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and autophagy through the TNF (Tumor necrosis factor) receptor-associated factor 6 (TRAF6)-evolutionarily conserved signaling ...
Mi-Jeong Kim, Yoon Min, Ji Seon Im, Juhee Son, Joo Sang Lee, Ki-Young Lee   +5 more
doaj   +1 more source

The caspase-6–p62 axis modulates p62 droplets based autophagy in a dominant-negative manner [PDF]

Cell Death & Differentiation, 2021
AbstractSQSTM1/p62, as a major autophagy receptor, forms droplets that are critical for cargo recognition, nucleation, and clearance. p62 droplets also function as liquid assembly platforms to allow the formation of autophagosomes at their surfaces.
Evelina Valionyte, Yi Yang, Sophie A. Griffiths, Amelia T. Bone, Elizabeth R. Barrow, Vikram Sharma, Boxun Lu, Shouqing Luo   +7 more
openaire   +2 more sources

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

Cell Reports, 2017
p62/SQSTM1 (p62) is a scaffolding protein that facilitates the formation and degradation of ubiquitinated aggregates via its self-interaction and ubiquitin binding domains.
YouJin Lee, Tsui-Fen Chou, Sara K. Pittman, Amy L. Keith, Babak Razani, Conrad C. Weihl   +5 more
doaj   +1 more source

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]

, 2019
The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine, Bock-Bierbaum, Tobias, Danieli, Alberto, Daumke, Oliver, Shi, Xiaoshan [u.v.m.], Su, Ming-Yuan, Sztacho, Martin, Trapannone, Riccardo, Turco, Eleonora, Witt, Marie   +9 more
core   +1 more source

Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62‐dependent manner

FEBS Open Bio, 2022
Homologous to E6AP C‐terminus (HECT)‐type E3 ubiquitin ligase SMAD‐specific E3 ubiquitin protein ligase 1 (Smurf1) was originally identified to ubiquitinate Smad protein in the TGF‐β/BMP signaling pathway.
Da Han, Shengzhen Li, Qin Xia, Xinyi Meng, Lei Dong   +4 more
doaj   +1 more source

Rag GTPases are cardioprotective by regulating lysosomal function. [PDF]

, 2014
The Rag family proteins are Ras-like small GTPases that have a critical role in amino-acid-stimulated mTORC1 activation by recruiting mTORC1 to lysosome.
Guan, Kun-Liang, Jewell, Jenna L, Kim, Young Chul, Mo, Jung-Soon, Park, Hyun Woo, Russell, Ryan C, Sadoshima, Junichi, Sciarretta, Sebastiano, Wu, Xiaohui   +8 more
core   +5 more sources

p62 acts as an oncogene and is targeted by miR-124-3p in glioma

Cancer Cell International, 2019
Background Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized.
Danni Deng, Kaiming Luo, Hongmei Liu, Xichen Nie, Lian Xue, Rong Wang, Yuan Xu, Jun Cui, Naiyuan Shao, Feng Zhi   +9 more
doaj   +1 more source

Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy

Biomedicines, 2022
Background: Carfilzomib, the proteasome inhibitor, can increase the overall survival rate of multiple myeloma (MM) patients undergoing targeted therapy.
Chin-Mu Hsu, Chia-Hung Yen, Shu-Chen Wang, Yi-Chang Liu, Chien-Tzu Huang, Min-Hong Wang, Tzer-Ming Chuang, Ya-Lun Ke, Tsung-Jang Yeh, Yuh-Ching Gau, Jeng-Shiun Du, Hui-Ching Wang, Shih-Feng Cho, Yuhsin Tsai, Chi-En Hsiao, Samuel Yien Hsiao, Hui-Hua Hsiao   +16 more
doaj   +1 more source