Results 191 to 200 of about 101,614 (324)

p62 limits Salmonella Typhimurium in macrophages through its role in cell signalling. [PDF]

Access Microbiol
Underwood D, Balci A, Solano-Collado V, Wilson HM, Baldassarre M, Spanò S.   +5 more
europepmc   +1 more source

USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies

Annals of the New York Academy of Sciences, EarlyView.
USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge, Hongying Sun, Jia Zhang, Yang Yang, Jian Mao, Cheliger   +5 more
wiley   +1 more source

AQP3 mediates autophagy through SIRT1/p62 signal to alleviate intestinal epithelial cell damage caused by sepsis [PDF]

Canmin Wang, Yingfang Hu, Yunfeng Song, Xinyi Hu   +3 more
openalex   +1 more source

A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination‐Mediated Degradation That Promotes Bacterial Infection

Plant Biotechnology Journal, EarlyView.
ABSTRACT Autophagy and the ubiquitin/26S proteasome system (UPS) play critical roles in the immune defence of the host against pathogen invasion. As a countermeasure, pathogens deploy effector proteins to subvert or hijack autophagy and UPS processes.
Yaqian Shi, Fang Fang, Xuejin Cui, Hongwei Shi, Zaiyu Yang, Xueyi Li, Changyong Zhou, Xuefeng Wang   +7 more
wiley   +1 more source

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review

Photochemistry and Photobiology, EarlyView.
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues   +6 more
wiley   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

TRIM39 aggravates hepatocellular carcinoma growth through targeting the p62-KEAP1-NRF2 axis. [PDF]

Sci Rep
Yang T, Chen Z, Yi F, Yang Y, Chu Z, Yang C, Ruan L, Sun J, Liu W.   +8 more
europepmc   +1 more source

SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation

, 2020
Cenxiao Fang, Jung A. Woo, Tian Liu, Xingyu Zhao, Sara Cazzaro, Yan Yan, Jenet Matlack, Teresa R. Kee, Patrick LePochat, David E. Kang   +9 more
openalex   +1 more source

The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation [PDF]

, 2006
Pilar Martı́n, María T. Díaz‐Meco, Jorge Moscat   +2 more
openalex   +1 more source

Applying lessons from limb muscle disuse and ageing to better understand ventilator‐induced diaphragm dysfunction

Experimental Physiology, EarlyView.
Abstract Mechanical ventilation (MV) is a life‐saving intervention applied to critically ill patients. A common consequence of MV is ventilator‐induced diaphragm dysfunction (VIDD), which is characterized by significant diaphragm atrophy and reduced contractile function. Older patients who receive MV are more likely to develop VIDD, have worse recovery,
P. H. C. Mesquita, J. L. Halle, J. D. Fuqua, B. F. Miller   +3 more
wiley   +1 more source