Results 31 to 40 of about 101,614 (324)
Autophagy and p62 in Cardiac Proteinopathy [PDF]
Circulation Research, 2011 Rationale: Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB R120G ) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy.
Qingwen, Zheng +3 more
openaire +2 more sources
A 3-D in vitro co-culture model of mammary gland involution. [PDF]
, 2014 Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru +5 more
core +3 more sources
Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]
, 2015 Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya +15 more
core +2 more sources
European Journal of Histochemistry, 2015 Autophagy assures cellular homeostasis, and gains increasing importance in cancer, where it impacts on carcinogenesis, propagation of the malignant phenotype and development of resistance.
A.M. Schläfli +4 more
doaj +1 more source
Molecular & Cellular Oncology, 2021 Membraneless condensates have recently caught the attention of biologists as hubs for cellular components required for catalysis of basic processes.
Afu Fu +3 more
doaj +1 more source
Military Medical Research, 2022 Background Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remains elusive.
Xue Zeng +9 more
doaj +1 more source
Expression Pattern of p62 in Primary Age-Related Tauopathy: Staging of p62 in PART
Frontiers in Aging Neuroscience, 2022 The present study analyzed the distribution pattern of p62 immunoreactivity in brains of primary age-related tauopathy (PART) and Braak NFT matched pre-AD and Alzheimer’s disease (AD) patients using immunohistochemistry in combination with semi-quantitative evaluation.
Xin Wang +9 more
openaire +3 more sources
Frontiers in Oncology, 2019 Glioma, especially glioblastoma, is pathologically characterized by high aggressiveness, which largely contributed to the ineffectiveness of current therapies.
Ruo Qiao Chen +11 more
doaj +1 more source
p62 links autophagy and Nrf2 signaling [PDF]
Free Radical Biology and Medicine, 2015 The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis that functions to protect cells against oxidative stress, environmental toxicants, and harmful chemicals through the induction of cytoprotective genes. To enforce strict regulation, cells invest a great deal of energy into the maintenance of the Nrf2 pathway to ensure rapid ...
Tao, Jiang +5 more
openaire +2 more sources
Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis [PDF]
, 2017 Mutations in the co- chaperone protein, CSPα, cause an autosomal dominant, adult-neuronal ceroid lipofuscinosis (AD-ANCL). The current understanding of CSPα function exclusively at the synapse fails to explain the autophagy-lysosome pathway (ALP ...
Benitez, Bruno A, Sands, Mark S
core +2 more sources