Results 61 to 70 of about 101,614 (324)
Targeting YAP‐p62 signaling axis suppresses the EGFR‐TKI‐resistant lung adenocarcinoma
Cancer Medicine, 2021 Background Despite the progress of advanced target therapeutic agents and immune checkpoint inhibitors, EGFR‐TKI resistance is still one of the biggest obstacles in treating lung cancer. Clinical studies with autophagy inhibitors are actively underway to
Hee Sun Park +14 more
doaj +1 more source
P62: PSYCHOLOGICAL INTERVENTIONS FOR FOOD ALLERGY ANXIETY – A CASE STUDY [PDF]
, 2023 openalex +1 more source
EXPRESSION AND PURIFICATION OF HUMAN p62 (HIS-TEV-mCherry-p62) v1
, 2023 This protocol describes how to express and purify human p62 tagged N-terminally with HIS and TEV. The expression is performed with E. coli Rosetta pLysS cells. The protein is purified via a HisTrap column and gel filtration (SEC).
openaire +1 more source
Parkin interacts with Ambra1 to induce mitophagy [PDF]
, 2011 Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease. Recent work has shown that Parkin translocates from the cytosol to depolarized mitochondria and induces their autophagic removal (mitophagy). However, the molecular
Cornelissen, Tom +6 more
core +2 more sources
Advanced Materials Interfaces, EarlyView.In situ SAXS/WAXS enables real‐time tracking of nanoparticle formation and evolution in exsolved and infiltrated Ni‐based perovskites under reducing conditions. The combined technique captures nucleation, growth, and coarsening dynamics with high temporal resolution, providing statistically robust insights into structural and morphological ...
Elena Vicente +4 more
wiley +1 more source
Selective Autophagy and Xenophagy in Infection and Disease
Frontiers in Cell and Developmental Biology, 2018 Autophagy, a cellular homeostatic process, which ensures cellular survival under various stress conditions, has catapulted to the forefront of innate defense mechanisms during intracellular infections.
Vartika Sharma +4 more
doaj +1 more source
TRIB3-P62 interaction, diabetes and autophagy
Oncotarget, 2015 Type 2 diabetes (T2D) and cancer are two common diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetic risk factors and diabetic medications.
Fang, Hua, Zhuo-Wei, Hu
openaire +2 more sources
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]
, 2011 Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham +49 more
core +3 more sources
Advanced Science, EarlyView.This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang +14 more
wiley +1 more source
p62 in Cancer: Signaling Adaptor Beyond Autophagy [PDF]
Cell, 2016 Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
Moscat, Jorge +2 more
openaire +4 more sources