Results 1 to 10 of about 100,348 (235)

Hepatitis C virus p7 regulates Core protein processing via signal peptide peptidase to promote virion assembly [PDF]

Journal of Virology
The hepatitis C virus (HCV) p7 protein is a viroporin essential for the production of infectious virus particles and has been implicated in regulating Core protein localization.
Ming-Jhan Wu, Patrick Healy, Chia-Wen Chang, Christoph Welsch, MinKyung Yi   +4 more
doaj   +2 more sources

Exercise and pre-habilitation with high whey-protein-based meal replacement therapy promote weight loss and preserve muscle mass before bariatric surgery

Asian Journal of Surgery, 2023
Background: Bariatric surgery is considered as an effective therapy for those with morbid obesity. Preoperative weight loss with a very low-calorie diet is commonly used to ease the bariatric surgery.
ChiouYi Ho, Siti Nuraini Mohd Samwil, Zuliehaiza Kahairudin, Norshariza Jamhuri, Adibah Abd Aziz   +4 more
doaj   +1 more source

The Network of Interactions Between Classical Swine Fever Virus Nonstructural Protein p7 and Host Proteins

Frontiers in Microbiology, 2020
Classical swine fever (CSF) is a highly contagious viral disease causing severe economic losses to the swine industry. As viroporins of viruses modulate the cellular ion balance and then take over the cellular machinery, blocking the activity of ...
Jindai Fan, Jindai Fan, Jindai Fan, Mengru Zhang, Mengru Zhang, Mengru Zhang, Chenchen Liu, Chenchen Liu, Chenchen Liu, Mengjiao Zhu, Mengjiao Zhu, Mengjiao Zhu, Zilin Zhang, Zilin Zhang, Zilin Zhang, Keke Wu, Keke Wu, Keke Wu, Zhaoyao Li, Zhaoyao Li, Zhaoyao Li, Wenhui Li, Wenhui Li, Wenhui Li, Shuangqi Fan, Shuangqi Fan, Shuangqi Fan, Chunmei Ju, Chunmei Ju, Chunmei Ju, Lin Yi, Lin Yi, Lin Yi, Hongxing Ding, Hongxing Ding, Hongxing Ding, Mingqiu Zhao, Mingqiu Zhao, Mingqiu Zhao, Jinding Chen, Jinding Chen, Jinding Chen   +41 more
doaj   +1 more source

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

eLife, 2020
Since the 1960s, a single class of agent has been licensed targeting virus-encoded ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other areas of medicine.
Joseph Shaw, Rajendra Gosain, Monoj Mon Kalita, Toshana L Foster, Jayakanth Kankanala, D Ram Mahato, Sonia Abas, Barnabas J King, Claire Scott, Emma Brown, Matthew J Bentham, Laura Wetherill, Abigail Bloy, Adel Samson, Mark Harris, Jamel Mankouri, David J Rowlands, Andrew Macdonald, Alexander W Tarr, Wolfgang B Fischer, Richard Foster, Stephen Griffin   +21 more
doaj   +1 more source

SPCS1-Dependent E2-p7 processing determines HCV Assembly efficiency.

PLoS Pathogens, 2022
Recent studies identified signal peptidase complex subunit 1 (SPCS1) as a proviral host factor for Flaviviridae viruses, including HCV. One of the SPCS1's roles in flavivirus propagation was attributed to its regulation of signal peptidase complex (SPC ...
Nabeel Alzahrani, Ming-Jhan Wu, Carla F Sousa, Olga V Kalinina, Christoph Welsch, MinKyung Yi   +5 more
doaj   +1 more source

GENETICAL STUDIES ON SOME ECONOMICAL TRAITS IN BREAD WHEAT (Triticum aestivum L.) [PDF]

Journal of Agricultural Chemistry and Biotechnology, 2010
This investigation aimed to study; (1)The mean performance of ten parents and their F1 diallel crosses, involving some Egyptian and exotic wheat germplasm for yield and its components. (2)The potentiality of heterosis expression, (3) General and specific
M. Abd El-Maksoud, E. Gebrel, R. Koumber, Z. Kosba   +3 more
doaj   +1 more source

Hepatitis C Virus P7—A Viroporin Crucial for Virus Assembly and an Emerging Target for Antiviral Therapy

Viruses, 2010
The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus ...
Eike Steinmann, Thomas Pietschmann
doaj   +1 more source

Semi-dynamic leach testing of densified silicon-based iodine waste forms [PDF]

RSC Advances
A contaminant of concern in nuclear waste, iodine must be immobilized in an iodine waste form (IWF) prior to long-term disposal. A conceptual corrosion release model (CCRM) is required to provide iodine release rates in performance modeling of nuclear ...
Amanda R. Lawter, Gemma G. Clark, Nancy Escobedo, Jeff Bonnett, Nathan Canfield, Seungrag Choi, Mark E. Bowden, Josef Matyas, R. Matthew Asmussen   +8 more
doaj   +1 more source

Determination of Combining Ability and Type of Gene Action Using Half-Diallel Cross Among Seven S6 White Maize Inbred Lines [PDF]

Journal of Plant Production, 2021
Seven S6 white maize inbred lines were derived from selfing of S4 inbred lines of two populations; three way cross-324 and Giza-2 were used as parents of a 7 x 7 half-diallel cross and were obtained on 21 F1 crosses.
I. N. Abd El-Zaher
doaj   +1 more source

Contribution of Alanine-76 and Serine Phosphorylation in α-Synuclein Membrane Association and Aggregation in Yeasts

Parkinson's Disease, 2011
In Parkinson's disease (PD), misfolded and aggregated α-synuclein protein accumulates in degenerating midbrain dopaminergic neurons. The amino acid alanine-76 in α-synuclein and phosphorylation at serine-87 and serine-129 are thought to regulate its ...
Michael Fiske, Stephanie Valtierra, Keith Solvang, Michael Zorniak, Michael White, Sara Herrera, Alina Konnikova, Rebecca Brezinsky, Shubhik DebBurman   +8 more
doaj   +1 more source