Molecular Therapy: Methods & Clinical Development, 2015 Accumulation of the nerve growth factor precursor (proNGF) and its receptor p75NTR have been associated with several neurodegenerative diseases in both brain and retina. However, whether proNGF contributes to microvascular degeneration remain unexplored.
Ahmed Y Shanab +3 more
doaj +1 more source
Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 2001 Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core
The MAL proteolipid is necessary for the overall apical delivery of membrane proteins in the polarized epithelial Madin-Darby canine kidney and Fischer rat thyroid cell lines [PDF]
, 2000 The MAL proteolipid has been recently demonstrated as being necessary for correct apical sorting of the transmembrane influenza virus hemagglutinin (HA) in Madin-Darby canine kidney (MDCK) cells.
Alonso, Miguel A. +3 more
core +2 more sources
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente +4 more
wiley +1 more source
The expression system affects the binding affinity between p75NTR and proNGF
Biochemistry and Biophysics ReportsProNGF (nerve growth factor) is a precursor of NGF and a signaling peptide exerting opposite effects on neuronal cells, i.e., apoptotic or neuritogenic.
Mami Hino +2 more
doaj +1 more source
Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]
, 2019 Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela +14 more
core +2 more sources
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Alzheimer's disease (AD) pathology extends beyond the brain to the neurosensory retina. Ubiquitin carboxyl‐terminal hydrolase L1 (UCH‐L1), a key enzyme in the ubiquitin‐proteasome system, has a synaptic protective function and was recently implicated in amyloid β‐protein (Aβ) plaque accumulation in AD brains. However, its expression
Altan Rentsendorj +14 more
wiley +1 more source
Upregulation of p75NTR by Histone Deacetylase Inhibitors Sensitizes Human Neuroblastoma Cells to Targeted Immunotoxin-Induced Apoptosis [PDF]
, 2022 Simona Dedoni +7 more
openalex +1 more source
Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. [PDF]
PLoS ONE, 2015 Gliogenesis under pathophysiological conditions is of particular clinical relevance since it may provide evidence for regeneration promoting cells recruitable for therapeutic purposes.
Kristel Kegler +5 more
doaj +1 more source
Organotypic culture of normal, dysplastic and squamous cell carcinoma-derived oral cell lines reveals loss of spatial regulation of CD44 and p75NTR in malignancy [PDF]
, 2012 Oral squamous cell carcinomas (OSCC) often arise from dysplastic lesions. The role of cancer stem cells in tumour initiation is widely accepted, yet the potential existence of pre-cancerous stem cells in dysplastic tissue has received little attention ...
Ademuyiwa +37 more
core +3 more sources