Results 101 to 110 of about 14,891 (243)

Homocysteine‐Driven Disruption of Neurotrophic and Inflammatory Circuits in the Hippocampus: Novel Insights into Alzheimer's Therapeutics with Rivastigmine and Ibuprofen

Alzheimer's &Dementia, Volume 21, Issue S7, December 2025.
Abstract Background Alzheimer's disease (AD) is characterized by cognitive decline, synaptic dysfunction, and neuronal loss, processes linked to neuroinflammation and impaired neurotrophic support. AD research focuses on understanding molecular mechanisms underlying neurodegeneration.
Gustavo Ricardo Krupp Prauchner, Osmar Vieira Ramires Junior, Angela Terezinha de Souza Wyse   +2 more
wiley   +1 more source

SorCS3 promotes the internalization of p75NTR to inhibit GBM progression

Cell Death and Disease, 2022
Glioblastoma (GBM) is a fatal malignancy caused by dysregulation of cellular signal transduction. Internalization plays a key role in maintaining signalling balance. Previous reports showed that Sortilin related VPS10 domain containing receptor 3 (SorCS3)
Yanqiu Zhang, Yue Li, Yuhua Fan, Xiaoyuan Zhang, Zhihong Tang, Jing Qi, Baoshan Zhao, Fuyuan Li, Xiaofeng Chen, Huan Liang, Haiyan Xu, Dongliang Li   +11 more
doaj   +1 more source

Nerve growth factor/p75 neurotrophin receptor–mediated sensitization of rat sensory neurons depends on membrane cholesterol [PDF]

, 2013
Nerve growth factor (NGF) is an important mediator in the initiation of the inflammatory response and NGF via activation of the p75 neurotrophin receptor (p75(NTR)) and downstream sphingomyelin signaling leads to significant enhancement of the ...
Khanna, R, Nicol, Grant D., Zhang, YH
core   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Fragment C of Tetanus Toxin : New Insights into Its Neuronal Signaling Pathway [PDF]

, 2012
When Clostridium tetani was discovered and identified as a Gram-positive anaerobic bacterium of the genus Clostridium, the possibility of turning its toxin into a valuable biological carrier to ameliorate neurodegenerative processes was inconceivable ...
Acheson, Aguilera, Ana C. Calvo, Anderson, Barati, Boquet, Borasio, Bordet, Brooks, Calappi, Carlton, Chaib-Oukadour, Chaib-Oukadour, Check, Chen, Chen, Ciriza, Coen, Conway, Cosman, Cowie, Deinhardt, Deinhardt, Deinhardt, Emsley, Evinger, Firor, Fishman, Flexner, Fotinou, Gil, Gil, Gil, Gil, Habermann, Habermann, Harvey, Helting, Herreros, Herreros, Humeau, Inserte, Ipsen, Jayaraman, Jayaraman, Johnson, Johnson, Johnson, José Aguilera, Lalli, Landsteiner, Larsen, Lazarovici, Louch, Manning, Manwaring, Martini, Mendieta, Menestrina, Miana-Mena, Miana-Mena, Miana-Mena, Mochida, Montal, Moreno-Igoa, Moreno-Igoa, Neubauer, Noguchi, Oliveira, Pelliccioni, Pellizari, Pilar Zaragoza, Raquel Manzano, Roaf, Rosario Osta, Roux, Rummel, Sara Oliván, Sherrington, Siade, Simpson, Sinha, Skaper, Skeldal, Sugiyama, Sutton, Thorne, Twiss, Ungar, Van Heyningen, Van Heyningen, Van Heyningen, Van Heyningen, Wang, Wassermann, Wright   +95 more
core   +3 more sources

Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis

Glia, Volume 73, Issue 12, Page 2407-2426, December 2025.
Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf, Sandor Nietzsche, Martin Westermann, Eva M. Neuhaus   +3 more
wiley   +1 more source

Schwann Cell Apoptosis and p75NTR siRNA

Iranian Journal of Allergy, Asthma and Immunology, 2011
The p75 pan-neurotrophin receptor (p75NTR) plays a pivotal role in linking the immune system with the nervous system. p75NTR is required for the development of several characteristic features of allergic asthma.
Masoumeh Firouzi, Farzaneh Sabouni, Abdolkhaleg Deezagi, Zahra Hassannejad Pirbasti, Fatemeh Poorrajab, Vafa Rahimi-Movaghar   +5 more
doaj  

Isolation and characterization of neural crest progenitors from adult dorsal root ganglia [PDF]

, 2007
After peripheral nerve injury, the number of sensory neurons in the adult dorsal root ganglia (DRG) is initially reduced but recovers to a normal level several months later. The mechanisms underlying the neuronal recovery after injury are not clear. Here,
Abrous, Ballas, Bedford, Belmadani, Berg, Bixby, Bondurand, Campos, Cecchini, Cheung, Chie, Ciaroni, Corti, Cosgaya, Crane, Devor, Elson, Eng, Evonne Hwee Min Say, Farel, Farel, Farinas, Fernandes, Greenwood, Grothe, Groves, Groves, Groves, Hagedorn, Hong-Yun Li, Hu, Iwashita, Jessen, Kleber, Kruger, Kruger, Kuo, La Forte, Le Douarin, Lee, Lendahl, Lindsay, Lo, Lopez, Ma, Marmigere, Maro, Ming, Mohammed, Molofsky, Mori, Morrison, Murphy, Namaka, Okano, Popken, Pover, Rask-Andersen, Real, Sauka-Spengler, Sommer, Stemple, Steventon, Stewart, Svenningsen, Tomita, Tucker, Valero, Wiggins, Wong, Xian, Xin-Fu Zhou, Yamashita, Yoon, Young, Yun, Zhou, Zhou   +77 more
core   +1 more source

Stroke: Epidemiology, Risk Factors, Signaling Pathways, and Clinical Management

MedComm, Volume 6, Issue 12, December 2025.
Overview of clinical management strategies for acute and rehabilitative phases of stroke. The clinical management of IS involves reperfusion therapy during the acute phase and general supportive therapy, including blood pressure management, glucose management, antiplatelet therapy, and rehabilitation therapy during the recovery phase. Stem cell therapy
He Ren, Yuchun Liu, Mingyue Zhao, Hangyu Shen, Sheng Nie, Xiang Gao, Yi Huang   +6 more
wiley   +1 more source

Characterization of NGF, trkANGFR, and p75NTR in Retina of Mice Lacking Reelin Glycoprotein

International Journal of Cell Biology, 2014
Both Reelin and Nerve Growth Factor (NGF) exert crucial roles in retinal development. Retinogenesis is severely impaired in E-reeler mice, a model of Reelin deficiency showing specific Green Fluorescent Protein expression in Rod Bipolar Cells (RBCs ...
Bijorn Omar Balzamino, Filippo Biamonte, Graziana Esposito, Ramona Marino, Francesca Fanelli, Flavio Keller, Alessandra Micera   +6 more
doaj   +1 more source