p75NTR−/− mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/β‐catenin pathway [PDF]
Cell Proliferation, 2020 The aim of this study was to investigate the role of p75 neurotrophin receptor (p75NTR) in regulating the mouse alveolar bone development and the mineralization potential of murine ectomesenchymal stem cells (EMSCs).
Yingying Wang +9 more
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Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis [PDF]
Journal of Neuroinflammation, 2020 Nerve growth factor (NGF) and its receptors, tropomyosin receptor kinase A (TrkA) and pan-neurotrophin receptor p75 (p75NTR), are known to play bidirectional roles between the immune and nervous system.
Nickoleta Delivanoglou +10 more
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Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression
Frontiers in Cellular Neuroscience, 2019 Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75NTR has been identified as a positive modulator for Schwann
Nádia P. Gonçalves +13 more
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Jiawei Kongsheng Zhenzhong Pill (JKZP) Alleviates Chronic Cerebral Hypoperfusion-Induced Hippocampal Synaptic Damage via S100A10/tPA/BDNF Pathway. [PDF]
Brain BehavABSTRACT Aims To evaluate the effects of Jiawei Kongsheng Zhenzhong Pill (JKZP) on rats with ischemic mild cognitive impairment (MCI) and investigate the underlying mechanisms. Methods The components of JKZP were analyzed using Q‐Orbitrap high‐resolution mass spectrometry (HRMS).
Wu Q +8 more
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SorCS3 promotes the internalization of p75NTR to inhibit GBM progression
Cell Death and Disease, 2022 Glioblastoma (GBM) is a fatal malignancy caused by dysregulation of cellular signal transduction. Internalization plays a key role in maintaining signalling balance. Previous reports showed that Sortilin related VPS10 domain containing receptor 3 (SorCS3)
Yanqiu Zhang +11 more
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Acta Neuropathologica Communications, 2019 The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression of the p75NTR pan-neurotrophin
Viviana Pérez +13 more
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NGF and P75NTR gene expression is associated with the hepatic fibrosis stage due to viral and non-viral causes. [PDF]
PLoS ONE, 2015 This study evaluated the relative mRNA expression levels of nerve growth factor (NGF) and the p75 neurothrophin receptor (p75NTR) in different histological stages of human liver disease.
Ednelza da Silva Graça Amoras +10 more
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Merlin status regulates p75NTR expression and apoptotic signaling in Schwann cells following nerve injury [PDF]
Neurobiology of Disease, 2015 After nerve injury, Schwann cells (SCs) dedifferentiate, proliferate, and support axon regrowth. If axons fail to regenerate, denervated SCs eventually undergo apoptosis due, in part, to increased expression of the low-affinity neurotrophin receptor ...
Iram Ahmad +5 more
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Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures [PDF]
Cerebral Cortex, 2016 The brain-derived neurotrophic factor (BDNF) is synthesized as a precursor, namely proBDNF, which can be processed into mature BDNF (mBDNF). Evidences suggest that proBDNF signaling through p75NTR may account for the emergence of neurological disorders ...
Baptiste Riffault +9 more
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Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model [PDF]
Scientific Reports, 2018 Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the ...
Sally L. Elshaer, Azza B. El-Remessy
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