p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
Frontiers in Cell and Developmental Biology, 2023 The circadian clock plays a critical role in dentomaxillofacial development. Tooth biomineralization is characterized by the circadian clock; however, the mechanisms underlying the coordination of circadian rhythms with tooth development and ...
Bo Xie +10 more
doaj +3 more sources
Neurotophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells [PDF]
Frontiers in Immunology, 2017 Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the
Andreas Dahl +19 more
core +8 more sources
Neurobiology of Disease, 2004 We have previously demonstrated that high concentrations of nerve growth factor suppress neurite outgrowth from sensory neurons. Inhibition could be mediated by either the p75NTR or TrkA receptor.
Anna M. Conti +3 more
doaj +2 more sources
Phenotype changes of oral epithelial stem cells after in vitro culture [PDF]
Brazilian Oral Research, 2020 The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype.
Felipe Perozzo DALTOE +4 more
doaj +1 more source
A review of studies on the roles of p75NTR in the tooth development and tissue regeneration [PDF]
Yixue xinzhi zazhi, 2020 p75NTR, a low affinity neurotrophic factor receptor, is considered as a typical neural crest marker. It has been reported that p75NTR not only played an important role in the proliferation, migration, differentiation, survival and apoptosis of neural ...
Shi-Ting LI, Xia YU, Xiu-Jie WEN
doaj +1 more source
p75NTR signal transduction suppressed by BFAR and p75NTR interactions [PDF]
Science China Life Sciences, 2012 p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death signals. To analyze the regulatory mechanisms of p75NTR, the present study utilized a new membrane yeast two-hybrid system to screen a ...
Li, HongMei, Shi, HuiLi, Huo, KeKe
openaire +2 more sources
p75 neurotrophin receptor: a prototype therapeutic target modulating fundamental mechanisms of degeneration and glial function in Alzheimer’s and related dementias [PDF]
Alzheimers DementAbstract Background In AD and ADRDs, multiple pathological processes including those promoted by amyloid, pathological forms of tau and dysfunction of glial and innate immunity functions contribute to the functional failure and degeneration of synapses.
Longo F.
europepmc +2 more sources
p75NTR‐dependent modulation of cellular handling of reactive oxygen species [PDF]
Journal of Neurochemistry, 2009 AbstractOur previous studies demonstrated that p75NTR confers protection against oxidative stress‐induced apoptosis upon PC12 cells; however, the mechanisms responsible for this effect are not known. The present studies reveal decreased mitochondrion membrane potential and increased generation of reactive oxygen species (ROS) in p75NTR‐deficient PC12 ...
Zhiping Mi +3 more
openalex +3 more sources
A Rapid Method to Immortalize Schwann Cells. [PDF]
Pediatr DiscovABSTRACT The study of cells aids in comprehending the pathophysiology of diseases. However, obtaining a large number of primary cells in a short period is challenging, and they senesce and die after repeated passages. Therefore, establishing immortalized cell lines is necessary for conducting cellular experiments.
Zhang Y +5 more
europepmc +2 more sources
Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion. [PDF]
Adv Sci (Weinh)Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ahlgreen OA +13 more
europepmc +2 more sources