Results 61 to 70 of about 10,177 (244)
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity
Cell Reports, 2016 Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Bernat Baeza-Raja +16 more
doaj +1 more source
p75NTR in Huntington's disease: beyond the basal ganglia
Oncotarget, 2015 Huntington’s disease (HD) is a fatal neurodegenerative disorder with a characteristic phenotype including chorea and dystonia, uncoordinated fine movements, cognitive decline and psychiatric disturbances. Even though the clinical diagnosis of HD relies on the manifestation of motor abnormalities, the associated memory ...
Brito, Verónica, Ginés Padrós, Silvia
openaire +4 more sources
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin [PDF]
Journal of Molecular Biology, 2010 Nerve growth factor (NGF) is initially synthesized as a precursor, proNGF, that is cleaved to release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive precursor but acts as a signaling ligand distinct from its mature counterpart.
Risa Torkin +7 more
openaire +3 more sources
Journal of Cellular and Molecular Medicine, 2020 Human periodontal ligament stem cells (hPDLSCs) are a promising source in regenerative medicine. Due to the complexity and heterogeneity of hPDLSCs, it is critical to isolate homogeneous hPDLSCs with high regenerative potential.
Jun Li +9 more
semanticscholar +1 more source
p75NTR‐dependent modulation of cellular handling of reactive oxygen species [PDF]
Journal of Neurochemistry, 2009 AbstractOur previous studies demonstrated that p75NTR confers protection against oxidative stress‐induced apoptosis upon PC12 cells; however, the mechanisms responsible for this effect are not known. The present studies reveal decreased mitochondrion membrane potential and increased generation of reactive oxygen species (ROS) in p75NTR‐deficient PC12 ...
Zeljka Korade Mirnics +3 more
openaire +3 more sources
Pediatric Investigation, EarlyView.Retinoma, a benign tumor caused by biallelic retinoblastoma gene (RB1) inactivation, offers key insights into retinoblastoma development and oncogenesis. This review explores its molecular genetics, clinical features, diagnosis, management, and potential implications for advancing the prevention and treatment of retinoblastoma.
Panagiotis Toumasis +3 more
wiley +1 more source
Cells, 2020 Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs.
V. Pallottini +8 more
semanticscholar +1 more source
eLife, 2020 Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day.
Brandon Podyma +8 more
doaj +1 more source
PROTEOMICS, EarlyView.ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou +2 more
wiley +1 more source
In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review
Epilepsia, EarlyView.Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik +5 more
wiley +1 more source