Results 61 to 70 of about 14,891 (243)

The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation

eLife, 2020
Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day.
Brandon Podyma, Dove-Anna Johnson, Laura Sipe, Thomas Parks Remcho, Katherine Battin, Yuxi Liu, Sung Ok Yoon, Christopher D Deppmann, Ali Deniz Güler   +8 more
doaj   +1 more source

Expression of CD90 and P75NTR stem cell markers in ameloblastomas : a possible role in their biological behavior [PDF]

, 2016
Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these ...
Coelho, Carolinne Almeida, Cury, Sérgio Elias Vieira, Decurcio, Daniel de Almeida, Dias, Andrielle, Guerra, Eliete Neves, Mantesso, Andrea, Marques, Ana Elizia Mascarenhas, Silva, Brunno Santos de Freitas, Silva, Fernanda Paula Yamamoto   +8 more
core   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Toluene Alters p75NTR Expression in the Rat Brainstem

INDUSTRIAL HEALTH, 2004
Toluene is a neurotoxic organic solvent widely used in industry. Acute toluene administration in rats induced a significant increase in the numbers of neural cells immunostained for p75NTR in several brainstem regions, such as the raphe magnus and the nucleus of the solitary tract, as well as in the lateral reticular, gigantocellular, vestibular and ...
Jesús, Pascual, Lena, Morón, Jon, Zárate, Arantza, Gutiérrez, Itziar, Churruca, Enrique, Echevarría   +5 more
openaire   +3 more sources

p75NTR/proBDNF Modulates Basal Cell Carcinoma (BCC) Immune Microenvironment via Necroptosis Signaling Pathway

Journal of Immunology Research, 2021
Basal cell carcinoma (BCC) is the most common skin cancer. While most of the basal cell carcinomas were localized lesion and can be easily managed, the treatment options to the advanced basal cell carcinomas are still remarkably limited. In recent years,
Qingli Lu, Yuanyuan Qu, Yuan Ding, Xiaojing Kang   +3 more
doaj   +1 more source

Integrated single‐nucleus and spatial analysis of PS19 tauopathy mice finds aberrant neuronal to glial communication is ameliorated by neurotrophin modulator LM11A‐31 [PDF]

Alzheimers Dement
Abstract Background Tau pathology is a key driver of neurodegeneration in Alzheimer’s Disease (AD) and related dementia. Previous studies have shown that LM11A‐31 (C31)—a small molecule modulator of the p75 neurotrophin receptor (p75NTR)—reduced pathological tau accumulation, preserved synaptic plasticity, reduced degeneration of synaptic spines, and ...
Butler R, Yang T, Han C, Guen Y, Tran K, Liu H, Leng S, Massa S, Longo F.   +8 more
europepmc   +2 more sources

p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells [PDF]

, 2007
Although our understanding of adult neurogenesis has increased dramatically over the last decade, confusion still exists regarding both the identity of the stem cell responsible for neuron production and the mechanisms that regulate its activity. Here we
Bartlett, P. F., Coulson, E. J., Merson, T. D., Sotthibundhu, A., Young, K. M.   +4 more
core   +1 more source

Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms

Advanced Science, EarlyView.
This study reveals that Schwann cell FDFT1‐mediated cholesterol synthesis is essential for peripheral nerve regeneration via dual roles: as a structural component for myelin and as a metabolic signal that upregulates IGF1. IGF1 promotes axonal growth through paracrine action and enhances Schwann cell differentiation/ myelination via an intrinsic IGF1R ...
Shuyi Xu, Ye He, Ying Zou, Mengyao Zhao, Jiaqi Zhang, Yizhou Xu, Jiale Cai, Xiongbo Luo, Xinrui Ma, Saini Wu, Yuling Huang, Xianghai Wang, Jiasong Guo   +12 more
wiley   +1 more source

The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes [PDF]

, 2005
The boundary cap (BC) is a transient neural crest-derived group of cells located at the dorsal root entry zone (DREZ) that have been shown to differentiate into sensory neurons and glia in vivo.
Cederberg, A, Enerback, S, Ernfors, P, Heglind, M, Hjerling-Leffler, J, Koltzenburg, M, Marmigere, F   +6 more
core   +2 more sources

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source