Results 1 to 10 of about 6,896 (141)

Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H2O2‐Damaged PC12 Cells [PDF]

Immunity, Inflammation and Disease
Background Spinal cord injury (SCI) leads to severe neurological dysfunction. Current therapeutic strategies remain limited, with poor recovery rates. Oxidative stress and ferroptosis are key mechanisms underlying secondary SCI.
Zongyu Zhang, Zhijing Zhou, Peng Zhang, Yongfeng Huo   +3 more
doaj   +2 more sources

Paeoniflorin ameliorates depressive behaviours by modulating microbiota–gut–brain axis functions [PDF]

General Psychiatry
Background Major depressive disorder (MDD), characterised by persistent anhedonia and elevated suicide risk, represents a global mental health challenge. Recent studies suggest a link between gut–brain axis dysfunction and depression.
Hui Yang, Bin Yuan, Siyu Chen, Sha Zhang, Dan Pan, Fushun Wang, Da Tang, Daoqun Song, Jason H Huang, Mingchen Jiang, Qiuyue Xu   +10 more
doaj   +2 more sources

Influence of paeoniflorin dietary supplementation on growth performance, antioxidant status, blood parameters, carcass characteristics and meat quality in broiler chickens [PDF]

Veterinary and Animal Science
Paeonia lactiflora Pall, known for its antioxidative and anti-apoptotic properties, is a traditional Chinese medicine. To address the growing demand for animal protein, large-scale commercial broiler production systems often induce excessive stress ...
Yefei Zhou, Cunyi Qiu, Zhiding Zhou, Dunlin Zhang, Yao Cai, Jun Yuan, Shanguo Mao   +6 more
doaj   +2 more sources

Paeoniflorin improves functional recovery through repressing neuroinflammation and facilitating neurogenesis in rat stroke model [PDF]

PeerJ, 2021
Background Microglia, neuron, and vascular cells constitute a dynamic functional neurovascular unit, which exerts the crucial role in functional recovery after ischemic stroke.
Hongli Tang, Leiruo Wu, Xixi Chen, Huiting Li, Baojun Huang, Zhenyang Huang, Yiyang Zheng, Liqing Zhu, Wujun Geng   +8 more
doaj   +2 more sources

Paeoniflorin inhibits APEC-induced inflammation in HD11 cells through the NF-κB signaling pathway by activating CB2R [PDF]

Poultry Science
Avian pathogenic Escherichia coli (APEC) is a bacterial pathogen that threatens poultry reproduction by inciting systemic inflammation and leading to chicken colibacillosis.
Siyang Shen, Bendong Fu, Guang Tian, Shiyuan Qin, Zhengfei Tan, Chengwen Song, Pengfei Yi, Luyuan Peng   +7 more
doaj   +2 more sources

Repeated topical paeoniflorin attenuates postoperative pain and accelerates cutaneous fibroblast proliferation in mice

Journal of Pharmacological Sciences, 2023
This study investigated whether the repeated topical paeoniflorin inhibits postoperative pain in mice. An incision of the plantar skin and underlying muscle of the hind paw elicits acute postoperative pain.
Tsugunobu Andoh, Momoka Goto
doaj   +1 more source

Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen and biofilm formation

Frontiers in Pharmacology, 2023
Paeoniflorin is one of the important components in Paeoniaceae plants. In this study, we used Caenorhabditis elegans as a model host and Pseudomonas aeruginosa as a bacterial pathogen to investigate the possible role of paeoniflorin treatment against P ...
Yuxing Wang, Le Zhang, Xiaoan Yuan, Dayong Wang   +3 more
doaj   +1 more source

Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma via K63-Linked C-Met Polyubiquitination-Dependent Autophagic Degradation

Frontiers in Oncology, 2022
Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied in experimental models and clinical trials for cancer treatment because of its anti-cancer property.
Zhi Liu, Zhaotao Wang, Danmin Chen, Xiaorui Liu, Guoyong Yu, Yan Zhang, Chen Chen, Ruxiang Xu, Yezhong Wang, Ru-en Liu   +9 more
doaj   +1 more source

Paeoniflorin mitigates high glucose-induced lifespan reduction by inhibiting insulin signaling in Caenorhabditis elegans

Frontiers in Pharmacology, 2023
In organisms, high glucose can cause several aspects of toxicity, including the lifespan reduction. Paeoniflorin is the major component of Paeoniaceae plants. Nevertheless, the possible effect of paeoniflorin to suppress high glucose toxicity in reducing
Tianwen Liu, Tianwen Liu, Ziheng Zhuang, Dayong Wang   +3 more
doaj   +1 more source

Paeoniflorin in Paeoniaceae: Distribution, influencing factors, and biosynthesis

Frontiers in Plant Science, 2022
Paeoniflorin, a monoterpene glucoside, is increasingly used in the clinical treatment of many diseases because it has a variety of pharmacological activities.
Xiao-Xiao Zhang, Xiao-Xiao Zhang, Jia-Qi Zuo, Yi-Ting Wang, Hui-Yun Duan, Jun-Hui Yuan, Yong-Hong Hu   +6 more
doaj   +1 more source