Results 31 to 40 of about 6,965 (203)

Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism

Pharmaceutical Biology, 2019
Context: Paeoniflorin is reported to possess numerous pharmacological activities. Paeoniflorin and glycyrrhizin are always used together for the treatment of disease in China clinics; however, the drug–drug interaction between glycyrrhizin and ...
Hongjuan Sun, Jingfeng Wang, Juan Lv
doaj   +1 more source

Quantification of Paeoniflorin by Fully Validated LC–MS/MS Method: Its Application to Pharmacokinetic Interaction between Paeoniflorin and Verapamil

Molecules, 2022
A rapid, sensitive, and specific LC-MS/MS method was developed and fully validated for the detection of paeoniflorin only in rat plasma, and applied to pharmacokinetic studies, including intravenous, multi-dose oral and combined administrations with verapamil.
Bin Bao, Yonglin Zhao, Huan Gong, Songshan Shi, Huijun Wang, Shunchun Wang   +5 more
openaire   +3 more sources

Microneedle-Assisted Percutaneous Delivery of Paeoniflorin-Loaded Ethosomes [PDF]

Molecules, 2018
Paeoniflorin, the main component of total glucosides of paeony (TGP), shows good therapeutic effects in arthritis, but has low bioavailability when administered orally. Avoiding such a deficiency for topical administration would expand its clinical application.
Yahua Cui, Yujia Mo, Qi Zhang, Wanwan Tian, Yutao Xue, Jie Bai, Shouying Du   +6 more
openaire   +3 more sources

The Study of a Novel Paeoniflorin-Converting Enzyme from Cunninghamella blakesleeana

Molecules, 2023
Paeoniflorin is a glycoside compound found in Paeonia lactiflora Pall that is used in traditional herbal medicine and shows various protective effects on the cardio-cerebral vascular system.
Yiheng Ye, Hairun Pei, Xueli Cao, Xueying Liu, Zhanghan Li, Biying Wang, Yan Pan, Jimin Zheng   +7 more
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Absorption and Excretion of Paeoniflorin in Rats

Journal of Pharmacy and Pharmacology, 1995
Abstract The absorption and excretion of paeoniflorin after intravenous and oral administration was studied in rats to evaluate the significance of paeoniflorin in the pharmacological action of Paeony root. The plasma concentration of paeoniflorin after intravenous administration at the doses of 0.5, 2.0 and 5.0 mg kg−1 ...
S, Takeda, T, Isono, Y, Wakui, Y, Matsuzaki, H, Sasaki, S, Amagaya, M, Maruno   +6 more
openaire   +2 more sources

Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder

Frontiers in Pharmacology, 2022
Objective: Major depressive disorder (MDD) is one of the most common psychiatric disorders, the diagnosis and treatment of MDD are major clinical issues. However, there is a lack of effective biomarkers and drugs diagnosis and therapeutics of MDD. In the
Sha Zhang, Sha Zhang, Mingchen Jiang, Shuxia Yan, Miaomiao Liang, Wei Wang, Bin Yuan, Qiuyue Xu   +7 more
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Pharmacokinetic Interaction of Paeoniflorin and Sinomenine: Pharmacokinetic Parameters and Tissue Distribution Characteristics in Rats and Protein Binding Ability In Vitro

Journal of Pharmacological Sciences, 2005
The root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in Chinese herbal medicine for the treatment of inflammatory and arthritic diseases.
Zhong Qiu Liu, Zhi Hong Jiang, Kelvin Chan, Hua Zhou, Yuen Fan Wong, Zhao Xiang Bian, Hong Xi Xu, Liang Liu   +7 more
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Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

Frontiers in Immunology, 2022
Epidemiological studies have shown that the incidence, prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) are increasing globally.
Wei Yu, Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu   +5 more
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Inhibition of Th1 and Th17 Cells by Medicinal Plants and Their Derivatives: A Systematic Review. [PDF]

, 2017
Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases.
Asadi-Samani, Majid., Bagheri, Nader., Rafieian-Kopaei, Mahmoud., shirzad, Hedayatollah.   +3 more
core   +1 more source

Integration of Metabolomics and Transcriptomics Reveals the Therapeutic Mechanism Underlying Paeoniflorin for the Treatment of Allergic Asthma

Frontiers in Pharmacology, 2019
Objectives: Asthma is a chronic airway inflammatory disease, which is characterized by airway remodeling, hyperreactivity and shortness of breath. Paeoniflorin is one of the major active ingredients in Chinese peony, which exerts anti-inflammatory and ...
Qiyang Shou, Qiyang Shou, Qiyang Shou, Lu Jin, Lu Jin, Jiali Lang, Jiali Lang, Qiyuan Shan, Zhunan Ni, Changpei Cheng, Qinglin Li, Huiying Fu, Gang Cao   +12 more
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