Results 31 to 40 of about 107,265 (203)

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients [PDF]

, 2002
BACKGROUND: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients ...
Beex, L.V. (Louk), Bendahl, P.O., Blankenstein, M.A. (Marinus), Borstnar, S., Broet, P., Brunner, N., Christensen, I.J., Cufer, T., Daver, A., Daxenbichler, G., Duffy, M.J. (Michael), Duggan, C., Eppenberger, U., Eppenberger-Castori, S. (Serenella), Ferno, M., Fiets, W.E., Foekens, J.A. (John), Harbeck, N. (Nadia), Janicke, F., Kates, R. (Ronald), Klijn, J.G.M. (Jan), Kueng, W., Lisboa, B.W., Look, M.P. (Maxime), Magdelenat, H., Manders, P. (Peggy), Martin, P.M., Meijer van Gelder, M.E. (Marion), O'Higgins, N., Peyrat , J.P., Putten, W.L.J. (Wim) van, Quillien, V., Ricolleau, G., Romain, S., Schmitt, M. (Manfred), Spyratos, F., Sweep, C.G., Thomssen, C. (Christoph), Ulm, K., Windbichler, G.   +39 more
core   +1 more source

Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study

Annals of Indian Academy of Neurology, 2020
Objective: Despite advances made in the treatment of ischemic stroke, it still remains one of the leading causes of mortality and disability worldwide.
Adina Hutanu, Mihaela Iancu, Smaranda Maier, Rodica Balasa, Minodora Dobreanu   +4 more
doaj   +1 more source

The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease

Journal of Inflammation Research, 2021
Monika Katko,1 Erika Galgoczi,1 Annamaria Erdei,1 Annamaria Gazdag,1 Eszter Berta,1 Miklos Bodor,1 Ildiko Seres,2 Ildiko Hircsu,1 Arpad Badics,1 Bernadett Ujhelyi,3 Livia Sira,1 Harjit Pal Bhattoa,4 Endre V Nagy1 1Division of Endocrinology, Department of
Katko M, Galgoczi E, Erdei A, Gazdag A, Berta E, Bodor M, Seres I, Hircsu I, Badics A, Ujhelyi B, Sira L, Bhattoa HP, Nagy EV   +12 more
doaj  

Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome [PDF]

, 2016
Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against thrombus formation. Elevated levels
Mossberg, Karin
core   +1 more source

Possible effect of genetic background in thrombophilia genes on clinical severity of patients with coronavirus disease-2019: A prospective cohort study

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022
Background and objective: Thrombotic and microangiopathic effects have been reported in Coronavirus Disease-2019 (COVID-19) patients. In the present study, we aimed to examine the relationship between hereditary thrombophilia factors and the clinical ...
Ozlem Sezer, Ozgur Gunal, Recai Aci, Adem Keskin   +3 more
doaj   +1 more source

Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome [PDF]

, 2018
We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS).
Avsic-Zupanc, Tatjana, Bellomo, Carla, Korva, Misa, Martinez, Valeria P., Mustonen, Jukka, Mäkelä, Satu, Papa, Anna, Strandin, Tomas, Vaheri, Antti   +8 more
core   +2 more sources

Inhibition of Plasminogen Activator Inhibitor 1 Attenuates Hepatic Steatosis but Does Not Prevent Progressive Nonalcoholic Steatohepatitis in Mice

Hepatology Communications, 2018
Plasminogen activator inhibitor 1 (PAI‐1), an essential regulator of fibrinolysis, is increasingly implicated in the pathogenesis of metabolic disorders, such as obesity and nonalcoholic fatty liver disease (NAFLD).
Anne S. Henkel, Sadiya S. Khan, Shantel Olivares, Toshio Miyata, Douglas E. Vaughan   +4 more
doaj   +1 more source

Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and endometriosis. Influence of PAI-1 polymorphism on PAI-1 antigen and mRNA expression

Thrombosis Research, 2008
Endometriosis is a benign gynecologic disease with a high prevalence. It is a multifactorial and polygenic entity in which the fibrinolytic system may be implicated. The objective of this study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in a group of women with and without endometriosis and to analyze the influence
Ramírez P, Gilabert-Estelles, Juan, Cosin, Raul, Gilabert, Juan, Espana, Francisco, Castello, Remedios, Chirivella, Melitina, Romeu, Alberto, Estelles, Amparo   +8 more
openaire   +4 more sources

PAI-1-dependent endothelial cell death determines severity of radiation-induced intestinal injury. [PDF]

PLoS ONE, 2012
Normal tissue toxicity still remains a dose-limiting factor in clinical radiation therapy. Recently, plasminogen activator inhibitor type 1 (SERPINE1/PAI-1) was reported as an essential mediator of late radiation-induced intestinal injury. However, it is
Rym Abderrahmani, Agnes François, Valerie Buard, Georges Tarlet, Karl Blirando, Mohammad Hneino, Aurelie Vaurijoux, Marc Benderitter, Jean-Christophe Sabourin, Fabien Milliat   +9 more
doaj   +1 more source

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking. [PDF]

PLoS ONE, 2015
BACKGROUND:Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a mild to moderate bleeding diathesis, which has been exclusively ascribed to the ...
Anna E Daniel, Ilse Timmerman, Igor Kovacevic, Peter L Hordijk, Luc Adriaanse, Ilkka Paatero, Heinz-Georg Belting, Jaap D van Buul   +7 more
doaj   +1 more source