PAI-1 augments mucosal damage in colitis [PDF]
Science Translational Medicine, 2019 SERPINE1/PAI-1 is elevated in the colon tissue of the most difficult-to-treat patients with IBD and leads to worsening of experimental colitis.
Gerard E. Kaiko +16 more
openaire +2 more sources
uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer [PDF]
, 2008 Background While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor growth and prolong survival ...
Wenyi Qin +32 more
core +2 more sources
Residual vein thrombosis and onset of post-thrombotic syndrome: Influence of the 4G/5G polymorphism of plasminogen activator inhibitor-1 gene [PDF]
, 2014 BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is the most important inhibitor of plasminogen activator. The functional 4G/5G polymorphism of the gene coding for PAI-1 may affect PAI-1 plasmatic activity, influencing the imbalance between ...
Amato, C +6 more
core +1 more source
The Scientific World Journal, 2014 Background. The mechanisms by which plasminogen activator inhibitor-1 (PAI-1) regulates inflammation, especially in acute respiratory distress syndrome (ARDS), are largely unknown. Objective.
Zhong-Hui Wang +3 more
doaj +1 more source
The effect of thyroid hormones on the white adipose tissue gene expression of PAI-1 and its serum concentration [PDF]
, 2009 Metabolic syndrome is associated with an increased risk of developing cardiovascular diseases and Plasminogen activator inhibitor 1 (PAI-1) overexpression may play a significant role in this process.
Biz, Carolina +6 more
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Prognostic Value of Plasminogen Activator Inhibitors in Breast Cancer
The International Journal of Biological Markers, 2002 The prognosis of cancer is primarily dependent on its potential to invade and metastasize. Data from both pre-clinical and clinical studies strongly suggest that serine proteases, as well as their inhibitors and receptor, play a central role in the ...
S. Borstnar MD, I. Vrhovec, T. Cufer
doaj +1 more source
Türk Biyokimya Dergisi, 2022 Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system.
Baltan Ecem +4 more
doaj +1 more source
Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study. [PDF]
, 2015 BackgroundObesity and obstructive sleep apnea syndrome (OSA) are highly prevalent and frequently overlapping conditions in children that lead to systemic inflammation, the latter being implicated in the various end-organ morbidities associated with these
Alonso-Álvarez, ML +7 more
core +1 more source
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]
, 2010 Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan +54 more
core +1 more source
The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin [PDF]
, 2006 BACKGROUND: Increased plasminogen activator inhibitor (PAI-1) levels lead to impaired fibrinolytic function associated with higher cardiovascular risk. PAI-1 expression may be regulated by different inflammatory cytokines such as interleukin-1alpha (IL-1)
Belzunce, M. (Miriam) +4 more
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