Results 41 to 50 of about 24,664,088 (323)

Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1–overexpressing mice [PDF]

Kidney International, 2005
Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of chronic kidney disease based on its up-regulated expression and on the beneficial effects of PAI-1 inhibition or depletion in experimental models. PAI-1 is a multifunctional protein and the mechanisms that account for its profibrotic effects have not been fully ...
Matsuo, Shunya, Lepez-Guisa, JeseS M., Cai, Xiaohe, Okamura, Daryl M., Alpers, Charles E., Bumgarner, Roger E., Peters, Mette A., Zhang, Guoqiang, Eddy, Allison A.   +8 more
openaire   +2 more sources

Dual Diverse Dynamic Reversible Actions of Ankaferd on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS

Turkish Journal of Hematology, 2012
OBJECTIVE: Ankaferd Blood Stopper (ABS) comprises a mixture of the plants Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum ve Urtica dioica.
Afife Karabıyık, Erkan Yılmaz, Şükrü Güleç, İbrahim Haznedaroğlu, Nejat Akar   +4 more
doaj   +1 more source

Non-invasive assessment of peritoneal membrane alterations

Bulletin de la Dialyse à Domicile, 2020
The peritoneal dialysis membrane is subject to remodelling in the course of peritoneal dialysis. In the absence of longitudinal morphological studies, this process is mainly studied indirectly by the investigation of changes in peritoneal transport.
Raymond Krediet, Alena Parikova
doaj   +1 more source

ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma

Cell Death and Disease, 2019
PAI-1 plays significant roles in cancer occurrence, relapse and multidrug resistance and is highly expressed in tumours. ACT001, which is currently in phase I clinical trials for the treatment of glioblastoma (GBM).
Xiaonan Xi, Ning Liu, Qianqian Wang, Yahui Chu, Zheng Yin, Yahui Ding, Yaxin Lu   +6 more
semanticscholar   +1 more source

Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: A single center study

Annals of Indian Academy of Neurology, 2020
Objective: Despite advances made in the treatment of ischemic stroke, it still remains one of the leading causes of mortality and disability worldwide.
Adina Hutanu, Mihaela Iancu, Smaranda Maier, Rodica Balasa, Minodora Dobreanu   +4 more
doaj   +1 more source

The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease

Journal of Inflammation Research, 2021
Monika Katko,1 Erika Galgoczi,1 Annamaria Erdei,1 Annamaria Gazdag,1 Eszter Berta,1 Miklos Bodor,1 Ildiko Seres,2 Ildiko Hircsu,1 Arpad Badics,1 Bernadett Ujhelyi,3 Livia Sira,1 Harjit Pal Bhattoa,4 Endre V Nagy1 1Division of Endocrinology, Department of
Katko M, Galgoczi E, Erdei A, Gazdag A, Berta E, Bodor M, Seres I, Hircsu I, Badics A, Ujhelyi B, Sira L, Bhattoa HP, Nagy EV   +12 more
doaj  

PAI-1 Overexpression in Valvular Interstitial Cells Contributes to Hypofibrinolysis in Aortic Stenosis

Cells, 2023
Aortic stenosis (AS) is associated with hypofibrinolysis, but its mechanism is poorly understood. We investigated whether LDL cholesterol affects plasminogen activator inhibitor 1 (PAI-1) expression, which may contribute to hypofibrinolysis in AS ...
Magdalena Kopytek, Michał Ząbczyk, Piotr Mazur, Anetta Undas, Joanna Natorska   +4 more
doaj   +1 more source

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Biomolecules, 2019
Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin-based
R. Samarakoon, Stephen P. Higgins, Craig E. Higgins, P. Higgins   +3 more
semanticscholar   +1 more source

Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking. [PDF]

PLoS ONE, 2015
BACKGROUND:Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a mild to moderate bleeding diathesis, which has been exclusively ascribed to the ...
Anna E Daniel, Ilse Timmerman, Igor Kovacevic, Peter L Hordijk, Luc Adriaanse, Ilkka Paatero, Heinz-Georg Belting, Jaap D van Buul   +7 more
doaj   +1 more source

Cisplatin-activated PAI-1 secretion in the cancer-associated fibroblasts with paracrine effects promoting esophageal squamous cell carcinoma progression and causing chemoresistance

Cell Death and Disease, 2018
Preoperative chemotherapy is a promising strategy for the treatment of esophageal squamous cell carcinoma (ESCC). Acquired resistance to chemotherapy is a major obstacle in improving patient prognosis. Cancer-associated fibroblasts (CAFs) are the primary
Y. Che, Jingnan Wang, Yuan Li, Zhiliang Lu, Jianbing Huang, Shouguo Sun, Shuangshuang Mao, Yuanyuan Lei, R. Zang, N. Sun, Jie He   +10 more
semanticscholar   +1 more source