Results 61 to 70 of about 107,265 (203)
Ukrainian Neurosurgical Journal, 2014 The purpose. To study relationship between plasminogen activator inhibitor-1 (PAI-1) level in plasma and -675 4G/5G polymorphism in the PAI-1 gene in patients with traumatic brain injury (TBI) in dynamics of treatment.Materials and methods ...
Oleksandr Potapov Jr, Oleksii Kmyta
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Korelacija aktivnosti PAI-1 u plazmi i polimorfizma 4G/5G u genu za PAI-1 [PDF]
, 2016 Hemostaza obuhvaća složene, međusobno povezane sustave čija je zadaća održati fluidnost krvi u tekućem stanju u krvožilnom sustavu, ali i omogućiti brzo stvaranje krvnog ugruška nakon ozljede krvne žile.
Čolić, Merima
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The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy
Drug Design, Development and Therapy, 2022 Ziyu Li,1 Wei Yang,1 Yong Yang,1 Jianbo Wu,2 Pei Luo,3 Yong Liu1,4,5 1Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Drug Discovery Research Center, Southwest Medical ...
Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y
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Physiological Reports, 2021 Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the therapeutic dose of tPA and uPA,
Galina Florova +12 more
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Interactive Effect of PAI-1 4G/5G Genotype and Salt Intake on PAI-1 Antigen [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 Abstract —Activation of the renin-angiotensin-aldosterone system (RAAS) is associated with increased circulating PAI-1 antigen and increased risk of thrombotic cardiovascular events. A 4G/5G polymorphism located 675 bp upstream from the transcription start site of the PAI-1 gene affects PAI-1 antigen ...
N J, Brown +5 more
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Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors [PDF]
, 2017 Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear.
Abitbol, M.M. +12 more
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PAI-1 secretion of endometrial and endometriotic cells is Smad2/3- and ERK1/2-dependent and influences cell adhesion [PDF]
, 2016 In the endometrium transforming growth factor-betas (TGF-ßs) are involved mainly in menstruation and endometriosis. After binding of the ligands to the high-affinity receptors, TGF-ß receptors (TBR1 and TBR2), TGF-ßs activate Smad signaling to modulate ...
Konrad, Lutz +6 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Atherosclerosis is an extremely complex disease process in which genetic, lipid, cellular, and immunologic factors combine to determine the location, severity, and timing of lesion development and clinical events.1 With the current epidemic of obesity and the metabolic syndrome, additional factors are now recognized as contributors to the vascular ...
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Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients [PDF]
, 2017 Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients.
Beex, Louk V. A. M. +39 more
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PAI-1 Produced Ex Vivo by Human Adipose Tissue Is Relevant to PAI-1 Blood Level [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 1999 Abstract —Human adipose tissue has been shown to produce plasminogen activator inhibitor type 1 (PAI-1). However, the importance of adipose tissue in the regulation of the PAI-1 plasma level is not known. The aim of this study was to investigate the relation between the production of PAI-1 by adipose tissue, plasma PAI-1 level,
P E, Morange +5 more
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