Results 61 to 70 of about 24,664,088 (323)

A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence

OncoTarget, 2016
Doxorubicin, an anthracycline antibiotic, is a commonly used anticancer drug. In spite of its widespread usage, its therapeutic effect is limited by its cardiotoxicity. On the cellular level, Doxorubicin-induced cardiotoxicity manifests as stress induced
A. Ghosh, R. Rai, Kitae E. Park, M. Eren, T. Miyata, Lisa D. Wilsbacher, D. Vaughan   +6 more
semanticscholar   +1 more source

Residual vein thrombosis and onset of post-thrombotic syndrome: Influence of the 4G/5G polymorphism of plasminogen activator inhibitor-1 gene [PDF]

, 2014
BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) is the most important inhibitor of plasminogen activator. The functional 4G/5G polymorphism of the gene coding for PAI-1 may affect PAI-1 plasmatic activity, influencing the imbalance between ...
Amato, C, CANINO, Baldassare, CORRADO, Egle, FERRARA, Filippo, INCALCATERRA, Egle, MELI, Francesco, MURATORI, Ida Maria   +6 more
core   +1 more source

PAI‐1, a target gene of miR‐143, regulates invasion and metastasis by upregulating MMP‐13 expression of human osteosarcoma

Cancer Medicine, 2016
Despite recent improvements in the therapy for osteosarcoma, 30–40% of osteosarcoma patients die of this disease, mainly due to its lung metastasis.
Mio Hirahata, M. Osaki, Y. Kanda, Yui Sugimoto, Y. Yoshioka, N. Kosaka, F. Takeshita, T. Fujiwara, A. Kawai, Hisao Ito, T. Ochiya, F. Okada   +11 more
semanticscholar   +1 more source

The effect of thyroid hormones on the white adipose tissue gene expression of PAI-1 and its serum concentration [PDF]

, 2009
Metabolic syndrome is associated with an increased risk of developing cardiovascular diseases and Plasminogen activator inhibitor 1 (PAI-1) overexpression may play a significant role in this process.
Biz, Carolina, Mattos, Ana Barbosa Marcondes de, Nascimento, Claudia Maria da Penha Oller do, Oliveira, Cristiane de, Oliveira, Juliana de., Oyama, Lila Missae, Ribeiro, Eliane Beraldi   +6 more
core   +1 more source

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription

Scientific Reports, 2016
Transforming growth factor β (TGF-β) signaling facilitates tumor development during the advanced stages of tumorigenesis, but induces cell-cycle arrest for tumor suppression during the early stages. However, the mechanism of functional switching of TGF-β
Yuki Kawarada, Yasumichi Inoue, Fumihiro Kawasaki, Keishi Fukuura, Koichi Sato, Takahito Tanaka, Yuka Itoh, H. Hayashi   +7 more
semanticscholar   +1 more source

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema

Physiological Reports, 2021
Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the therapeutic dose of tPA and uPA,
Galina Florova, René A. Girard, Ali O. Azghani, Krishna Sarva, Ann Buchanan, Sophia Karandashova, Christian J. DeVera, Danna Morris, Mignote Chamiso, Kathleen Koenig, Douglas B. Cines, Steven Idell, Andrey A. Komissarov   +12 more
doaj   +1 more source

Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma

Molecular Cancer, 2015
BackgroundAn increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive.
Ni Chen, M. Ren, Rong Li, Xin Deng, Y. Li, Kai Yan, Lamei Xiao, Yan Yang, Liqun Wang, M. Luo, W. Fay, Jianbo Wu   +11 more
semanticscholar   +1 more source

Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction [PDF]

, 2012
Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD,
Alzamendi, Ana, Gagliardino, Juan José, Garcia, María Elisa, Giovambattista, Andrés, Rebolledo, Oscar R., Spinedi, Eduardo   +5 more
core   +4 more sources