Results 201 to 210 of about 1,900,236 (234)

Systematic evaluation of MAIT and iNKT abundance as checkpoint blockade biomarkers. [PDF]

Front Immunol
Li Y, Chen L, Shan S, Wang H, Xing X, Zhang J.   +5 more
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Tumor-Infiltrating mregDCs Restrain Anti-Tumor Immunity in Early Relapse HCC. [PDF]

Adv Sci (Weinh)
Zhang Z, Ding L, Zhong Y, Feng H, Huang L, Huang W, Wang C, Östman A, Wang B, Zhou J, Fan J, Guo W, Wu L, Sun Y.   +13 more
europepmc   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

CD84 Expression Across Disease Stages and Leukemic Subpopulations in Acute Myeloid Leukemia. [PDF]

Cancers (Basel)
Martín-Herreros B, Cordón L, Rodríguez-Veiga R, Cano-Ferri I, Acuña-Cruz E, Torres-Miñana L, Navarro I, Lloret-Madrid P, Sempere A, Linares MD, Torres-Sánchez S, González-Romero E, Klein-González N, Pérez-Amill L, Senent L, Poveda-Andrés JL, De La Rubia J, Montesinos P, Guerreiro M.   +18 more
europepmc   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis. [PDF]

EBioMedicine
Wen X, Qu H, Benedyk-Machaczka M, Chen D, Sundberg E, Melén E, Altman M, Aulin C, Harris HE.   +8 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

The spatial landscape of the peritumoral interface: ARG1⁺ PMN-MDSCs reduction and NETosis as indicators of occult metastasis in tongue squamous cell carcinoma. [PDF]

Front Immunol
Zhang S, Xu J, Zhang C, Li X, Wang D, Li X, Guo C, Wang L.   +7 more
europepmc   +1 more source

SARS-CoV-2-specific T cells cross-react with tumor-associated antigens via molecular mimicry. [PDF]

J Transl Med
Ragone C, Mauriello A, Cavalluzzo B, Mangano S, Cembrola B, Ciotola N, Tagliamonte M, Buonaguro L.   +7 more
europepmc   +1 more source