Results 41 to 50 of about 39,498 (303)

Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease

Journal of Lipid Research
Post-translational lipid modification by palmitoylation is a reversible process crucial for maintaining cellular functionality. The palmitoyl acyltransferase zinc finger Asp-His-His-Cys motif-containing 5 (ZDHHC5) has garnered significant attention due ...
Huicong Liu, Shuo Wen, Chang Xu, Xiaohong Kang, Eryan Kong   +4 more
doaj   +1 more source

Multiple palmitoyl acyltransferases modify DAT palmitoylation (803.5)

The FASEB Journal, 2014
The dopamine transporter (DAT) mediates the reuptake of synaptic dopamine, thus regulating dopaminergic neurotransmission. DAT undergoes palmitoylation in which a saturated 16‐carbon palmitate group is linked to cysteine via a thioester bond. Palmitoylation regulates diverse aspects of neuronal protein trafficking and function, but its role in DAT ...
Danielle Rastedt, James Foster, Roxanne Vaughan   +2 more
openaire   +1 more source

Palmitoylation of solute carriers

Biochemical Pharmacology, 2023
Post-translational modifications are an important mechanism in the regulation of protein expression, function, and degradation. Well-known post-translational modifications are phosphorylation, glycosylation, and ubiquitination. However, lipid modifications, including myristoylation, prenylation, and palmitoylation, are poorly studied.
Cecilia E. Villanueva, Bruno Hagenbuch
openaire   +2 more sources

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

Journal of Clinical Investigation, 2023
RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27B, a
Jian-gang Ren, Bowen Xing, K. Lv, Rachel A O'Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, A. Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, E. Hexner, M. Philips, W. Tong   +14 more
semanticscholar   +1 more source

Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8*[S]

Journal of Lipid Research, 2009
Palmitoylation is a posttranslational modification that regulates protein trafficking and stability. In this study we investigated whether the endosomal soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) proteins syntaxin 7 ...
Yuhong He, Maurine E. Linder
doaj   +1 more source

Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis [PDF]

, 2017
Mutations in the co- chaperone protein, CSPα, cause an autosomal dominant, adult-neuronal ceroid lipofuscinosis (AD-ANCL). The current understanding of CSPα function exclusively at the synapse fails to explain the autophagy-lysosome pathway (ALP ...
Benitez, Bruno A, Sands, Mark S
core   +2 more sources

Palmitoylation promotes chaperone-mediated autophagic degradation of NLRP3 to modulate inflammation

Autophagy, 2023
The critical intracellular pattern recognition receptor NLRP3 senses pathogenic organisms and endogenous danger signals via forming inflammasomes to orchestrate innate immune responses.
Liqiu Wang, J. Cui
semanticscholar   +1 more source

Protein palmitoylation: an emerging regulator of inflammatory signaling and diseases

Frontiers in Immunology
Protein palmitoylation is a reversible lipid modification in which palmitoyl esters are covalently attached to cysteine residues of proteins. It controls various cellular physiological processes and alters protein stability, conformation, localization ...
Rong Chen, Rong Chen, Xiaohua Tang, Ying Wang, Bo Wang, Fei Mao, Fei Mao   +6 more
doaj   +1 more source

Post-translational palmitoylation of metabolic proteins

Frontiers in Physiology, 2023
Numerous cellular proteins are post-translationally modified by addition of a lipid group to their structure, which dynamically influences the proteome by increasing hydrophobicity of proteins often impacting protein conformation, localization, stability,
Kaitlyn M. J. H. Dennis, Lisa C. Heather
doaj   +1 more source