Results 41 to 50 of about 37,965 (302)

Palmitoylation of the Parkinson’s disease–associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis

Science Signaling, 2023
Synaptotagmin-11 (Syt11) is a vesicle-trafficking protein that is linked genetically to Parkinson’s disease (PD). Likewise, the protein α-synuclein regulates vesicle trafficking, and its abnormal aggregation in neurons is the defining cytopathology of PD.
Gary P. H. Ho, Erin Wilkie, Andrew J. White, D. Selkoe   +3 more
semanticscholar   +1 more source

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]

, 2019
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria, Bijata, Monika, Galil, Dalia Abdel, Gorinski, Nataliya, Kondaurova, Elena, Kulikova, Elizabeth [u.v.m.], Prasad, Sonal, Sigrist, Stephan, Wirth, Alexander, Zeug, Andre   +9 more
core   +1 more source

Palmitoylation of Metazoan Carotenoid Oxygenases [PDF]

Molecules, 2020
Abundant in nature, carotenoids are a class of fat-soluble pigments with a polyene tetraterpenoid structure. They possess antioxidant properties and their consumption leads to certain health benefits in humans. Carotenoid cleavage oxygenases (CCOs) are a superfamily of enzymes which oxidatively cleave carotenoids and they are present in all kingdoms of
Sheetal Uppal, Igor B. Rogozin, T.Michael Redmond, Eugenia Poliakov   +3 more
openaire   +4 more sources

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

Journal of Clinical Investigation, 2023
RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27B, a
Jian-gang Ren, Bowen Xing, K. Lv, Rachel A O'Keefe, Mengfang Wu, Ruoxing Wang, Kaylyn M. Bauer, A. Ghazaryan, George M. Burslem, Jing Zhang, Ryan M. O’Connell, Vinodh Pillai, E. Hexner, M. Philips, W. Tong   +14 more
semanticscholar   +1 more source

Protein palmitoylation and cancer [PDF]

EMBO reports, 2018
Protein S-palmitoylation is a reversible post-translational modification that alters the localization, stability, and function of hundreds of proteins in the cell. S-palmitoylation is essential for the function of both oncogenes (e.g., NRAS and EGFR) and tumor suppressors (e.g., SCRIB, melanocortin 1 receptor).
Pin‐Joe Ko, Scott J Dixon
openaire   +3 more sources

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

Palmitoylation and depalmitoylation defects [PDF]

Journal of Inherited Metabolic Disease, 2014
AbstractPalmitoylation describes the enzymatic attachment of a 16‐carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S‐palmitoylation) or irreversible (N‐palmitoylation) nature. In particular S‐palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl ...
openaire   +5 more sources

Membrane-associated proteins in giardia lamblia [PDF]

, 2018
The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza, Ropolo, Andrea Silvana, Touz, Maria Carolina   +2 more
core   +1 more source

Quantifying protein densities on cell membranes using super-resolution optical fluctuation imaging [PDF]

, 2017
Surface molecules, distributed in diverse patterns and clusters on cell membranes, influence vital functions of living cells. It is therefore important to understand their molecular surface organisation under different physiological and pathological ...
Benda, Aleš, Brdička, Tomáš, Cebecauer, Marek, Glatzová, Daniela, Kvíčalová, Zuzana, Lasser, Theo, Letschert, Sebastian, Levet, Florian, Lukeš, Tomáš, Sauer, Markus   +9 more
core   +10 more sources

Fatty acid synthesis promotes inflammasome activation through NLRP3 palmitoylation

bioRxiv, 2023
Inflammasomes are multi-protein complexes assembled by NOD-like receptor (NLR) family of proteins, which play critical roles in infectious, inflammatory and metabolic diseases.
Stuart Leishman, Najd M. Aljadeed, Liyunhe Qian, Shamshad Cockcroft, Jacques Behmoaras, P. Anand   +5 more
semanticscholar   +1 more source