Results 171 to 180 of about 23,036 (202)
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Mechanism of PAMAM Dendrimers Internalization in Hippocampal Neurons
Molecular Pharmaceutics, 2016Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with organelles, entry kinetics, and cargo release ...
Felipe, Vidal +5 more
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Fluorescence emission from PAMAM and PPI dendrimers
Journal of Colloid and Interface Science, 2007A strong fluorescence emission from poly(amido amine) (PAMAM) dendrimers with different terminal groups or a poly(propylene imine) (PPI) dendrimer was studied under different conditions by varying experimental parameters such as pH value, aging time, temperature, and concentration.
Dongjun, Wang, Toyoko, Imae, Masao, Miki
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DNA Assisted Self-Assembly of PAMAM Dendrimers
The Journal of Physical Chemistry B, 2014We report DNA assisted self-assembly of polyamidoamine (PAMAM) dendrimers using all atom Molecular Dynamics (MD) simulations and present a molecular level picture of a DNA-linked PAMAM dendrimer nanocluster, which was first experimentally reported by Choi et al. (Nano Lett., 2004, 4, 391-397). We have used single stranded DNA (ssDNA) to direct the self-
Mandal, Taraknath +2 more
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PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights
Chemistry – A European Journal, 2010AbstractShort double‐stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down‐regulate the expression of the targeted gene in a process known as RNA interference (RNAi). However, the success of gene silencing applications based on the use of synthetic siRNA critically depends on efficient intracellular delivery.
Pavan GM +8 more
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Supramolecular mimetic peroxidase based on hemin and PAMAM dendrimers
Chem. Commun., 2008An acid-base interaction between hemin and PAMAM dendrimers affords supramolecular non-covalent peroxidase systems whose catalytic activity is enhanced after spontaneous electrostatic self-assembling onto a solid surface.
CASTRICIANO MA +4 more
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Self‐assembled PAMAM dendrimer films
Advanced Materials, 1997Self‐assembly of starburst dendrimers into closely packed cells (see the optical micrograph in the Figure) is reported for generation 9.5 polyamidoamine (PAMAM) dendrimers solvent‐cast onto hydrophilic silicon substrates. It is shown that on the microscopic scale the cells are made up of a complex network of intertwined dendritic microfibrils ...
Simon A. Evenson, Jas Pal S. Badyal
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Influence of PAMAM dendrimers on the human insulin
AIP Conference Proceedings, 2015Dendrimers are specific class of polymeric macromolecules with wide spectrum of properties. One of the promising activities of dendrimers involves inhibition of protein fibril formation. Aggregation and fibrillation of insulin occurs in insulin-dependent diabetic patients after repeated administration, due to these processes being very easily triggered
Olga Nowacka +3 more
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Functionalization of PAMAM dendrimers with [RuIII(edta)(H2O)]−
Nitric Oxide, 2008The anchoring of K[Ru(III)(edta)(Cl)] on poly(amidoamine) dendrimers (PAMAM of three generations G(x)/Ru (x=0, 2 and 3)) through a peptide type bond yielded the aquo species, [Ru(III)(edta)(H2O)] on dendrimer surface, and upon NO exposure, yielded their nitrosyl analogues, G(x)/RuNO.
P G Z, Benini +2 more
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DNA-Templated Covalent Coupling of G4 PAMAM Dendrimers
Journal of the American Chemical Society, 2010Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to form covalently coupled dimers, trimers, and ...
Liu, Huajie +5 more
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On the Ability of PAMAM Dendrimers and Dendrimer/DNA Aggregates To Penetrate POPC Model Biomembranes
The Journal of Physical Chemistry B, 2010Poly(amido amine) (PAMAM) dendrimers have previously been shown, as cationic condensing agents of DNA, to have high potential for nonviral gene delivery. This study addresses two key issues for gene delivery: the interaction of the biomembrane with (i) the condensing agent (the cationic PAMAM dendrimer) and (ii) the corresponding dendrimer/DNA ...
Ainalem, Marie Louise +5 more
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