Results 1 to 10 of about 22,527 (223)

A DNA Vaccine Against Proadrenomedullin N-Terminal 20 Peptide (PAMP) Reduces Angiogenesis and Increases Lymphocyte and Macrophage Infiltration but Has No Effect on Tumor Burden in a Mouse Model of Lung Metastasis [PDF]

Vaccines
Background/Objectives: Nucleic acid-based anticancer vaccines are becoming a very active field in the fight against cancer. Here, our goal was to generate an oral DNA vaccine targeting the angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
Tom Kalathil Raju, Srdan Tadic, Pablo Garrido, Laura Ochoa-Callejero, Judit Narro-Íñiguez, Josune García-Sanmartín, Alfredo Martínez   +6 more
doaj   +2 more sources

Luciferase-mediated assay to detect the PAMP-triggered gene expression in transgenic Nicotiana benthamiana [PDF]

Plant Signaling & Behavior
Luciferase is one of the bioluminescence-producing agents, which was widely used as a reporter enzyme for constructing bioassay systems to study gene expression with high accuracy and within a broad dynamic spectrum.
Ola Barakat, Fushuang Zhang, Mengzhu Zeng, Yuanchao Wang   +3 more
doaj   +2 more sources

Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature

Open Biology, 2022
Since the publication of the Janeway's Pattern Recognition hypothesis in 1989, study of pathogen-associated molecular patterns (PAMPs) and their immuno-stimulatory activities has accelerated.
Anna E. Gauthier, Randi D. Rotjan, Jonathan C. Kagan   +2 more
doaj   +1 more source

Sensor Sensibility—HIV-1 and the Innate Immune Response

Cells, 2020
Innate immunity represents the human immune system’s first line of defense against a pathogenic intruder and is initiated by the recognition of conserved molecular structures known as pathogen-associated molecular patterns (PAMPs) by specialized ...
Xin Yin, Simon Langer, Zeli Zhang, Kristina M. Herbert, Sunnie Yoh, Renate König, Sumit K. Chanda   +6 more
doaj   +1 more source

TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

Cells, 2020
In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2).
Camilla Heiniö, Riikka Havunen, Joao Santos, Klaas de Lint, Victor Cervera-Carrascon, Anna Kanerva, Akseli Hemminki   +6 more
doaj   +1 more source

Adrenomedullin: Not Just Another Gastrointestinal Peptide

Biomolecules, 2022
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others.
Sonia Martínez-Herrero, Alfredo Martínez   +1 more
doaj   +1 more source

How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger

Journal of Extracellular Vesicles, 2020
Innate immunity is a first line of defence against danger. Exogenous pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) trigger innate immune responses through well-understood cellular pathways.
Yu Xiao, Tom Driedonks, Kenneth W. Witwer, Qian Wang, Hang Yin   +4 more
doaj   +1 more source

Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I. [PDF]

PLoS Pathogens, 2012
Viral infection of mammalian cells triggers the innate immune response through non-self recognition of pathogen associated molecular patterns (PAMPs) in viral nucleic acid.
Gretja Schnell, Yueh-Ming Loo, Joseph Marcotrigiano, Michael Gale   +3 more
doaj   +1 more source

Agonists of Receptors of the Innate Immunity and Defective Viral Particles as New Generation of Adjuvants

Эпидемиология и вакцинопрофилактика, 2018
Vaccines for many years act as one of the most effective and successfully used medicines. Vaccines obtained by traditional methods contain in their composition live, weakened or killed microorganisms (bacteria, viruses, etc.).
O. A. Svitich, V. F. Lavrov, P. I. Kukina, A. A. Iskandaryan, L. V. Gankovskaya, V. V. Zverev   +5 more
doaj   +1 more source

Comments on Comments

Names, 1989
Lena Peterson's comments (Names 37: 83–92) misinterpret my main point (in Names 33 [1985]: 111–18) on the connection between names and other noun phrases. A printing error in the 1985 article also caused confusion for many readers.
Bengt Pamp
doaj   +1 more source